Atrophy of the prostate gland - Revision history

Michael at 14:50, 4 August 2022

2022-08-04T14:50:04Z

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	\| LMDDx = [[prostate carcinoma]] - esp. [[atrophic prostate carcinoma]], [[atypical small acinar proliferation]]		\| LMDDx = [[prostate carcinoma]] - esp. [[atrophic prostate carcinoma]], [[atypical small acinar proliferation]]
	\| Stains =		\| Stains =
	\| IHC = AMACR -ve, p63 +ve (basal cells), CK34betaE12 +ve (basal cells)		\| IHC = [[AMACR]] -ve, [[p63]] +ve (basal cells), [[CK34betaE12]] +ve (basal cells)
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =

Michael at 00:23, 20 January 2015

2015-01-20T00:23:53Z

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	}}		}}
	'''Atrophy of the prostate gland''', also '''prostatic atrophy''', is a common change in the [[prostate gland]].		'''Atrophy of the prostate gland''', also '''prostatic atrophy''', is a common change in the [[prostate gland]].

	~~It usually is seen focally; thus, it is sometimes called '''partial prostatic atrophy'''.~~

	==General==		==General==
	*Considered to be the most common mimicker of [[prostate carcinoma]].<ref name=pmid18408595>{{Cite journal \| last1 = Wang \| first1 = W. \| last2 = Sun \| first2 = X. \| last3 = Epstein \| first3 = JI. \| title = Partial atrophy on prostate needle biopsy cores: a morphologic and immunohistochemical study. \| journal = Am J Surg Pathol \| volume = 32 \| issue = 6 \| pages = 851-7 \| month = Jun \| year = 2008 \| doi = 10.1097/PAS.0b013e31815a0508 \| PMID = 18408595 }}</ref>		*Considered to be the most common mimicker of [[prostate carcinoma]].<ref name=pmid18408595>{{Cite journal \| last1 = Wang \| first1 = W. \| last2 = Sun \| first2 = X. \| last3 = Epstein \| first3 = JI. \| title = Partial atrophy on prostate needle biopsy cores: a morphologic and immunohistochemical study. \| journal = Am J Surg Pathol \| volume = 32 \| issue = 6 \| pages = 851-7 \| month = Jun \| year = 2008 \| doi = 10.1097/PAS.0b013e31815a0508 \| PMID = 18408595 }}</ref>
	*Small glands (may mimic Gleason score 3 ~~pattern)~~.		*Small glands - may mimic [[Gleason score\|Gleason pattern]] 3.
	*Inflammatory atrophy seems to be related to [[HGPIN]] and [[prostate cancer]];<ref name=pmid10595928>{{Cite journal \| last1 = De Marzo \| first1 = AM. \| last2 = Marchi \| first2 = VL. \| last3 = Epstein \| first3 = JI. \| last4 = Nelson \| first4 = WG. \| title = Proliferative inflammatory atrophy of the prostate: implications for prostatic carcinogenesis. \| journal = Am J Pathol \| volume = 155 \| issue = 6 \| pages = 1985-92 \| month = Dec \| year = 1999 \| doi = 10.1016/S0002-9440(10)65517-4 \| PMID = 10595928 }}</ref> however, the epidemiology is not compelling that this is a significant (clinical) association.<ref name=pmid24129226>{{Cite journal \| last1 = Celma \| first1 = A. \| last2 = Servián \| first2 = P. \| last3 = Planas \| first3 = J. \| last4 = Placer \| first4 = J. \| last5 = Quilez \| first5 = MT. \| last6 = Arbós \| first6 = MA. \| last7 = de Torres \| first7 = I. \| last8 = Morote \| first8 = J. \| title = Clinical Significance of Proliferative Inflammatory Atrophy in Prostate Biopsy. \| journal = Actas Urol Esp \| volume = 38 \| issue = 2 \| pages = 122-126 \| month = Mar \| year = 2014 \| doi = 10.1016/j.acuro.2013.04.008 \| PMID = 24129226 }}</ref>		*Inflammatory atrophy seems to be related to [[HGPIN]] and [[prostate cancer]];<ref name=pmid10595928>{{Cite journal \| last1 = De Marzo \| first1 = AM. \| last2 = Marchi \| first2 = VL. \| last3 = Epstein \| first3 = JI. \| last4 = Nelson \| first4 = WG. \| title = Proliferative inflammatory atrophy of the prostate: implications for prostatic carcinogenesis. \| journal = Am J Pathol \| volume = 155 \| issue = 6 \| pages = 1985-92 \| month = Dec \| year = 1999 \| doi = 10.1016/S0002-9440(10)65517-4 \| PMID = 10595928 }}</ref> however, the epidemiology is not compelling that this is a significant (clinical) association.<ref name=pmid24129226>{{Cite journal \| last1 = Celma \| first1 = A. \| last2 = Servián \| first2 = P. \| last3 = Planas \| first3 = J. \| last4 = Placer \| first4 = J. \| last5 = Quilez \| first5 = MT. \| last6 = Arbós \| first6 = MA. \| last7 = de Torres \| first7 = I. \| last8 = Morote \| first8 = J. \| title = Clinical Significance of Proliferative Inflammatory Atrophy in Prostate Biopsy. \| journal = Actas Urol Esp \| volume = 38 \| issue = 2 \| pages = 122-126 \| month = Mar \| year = 2014 \| doi = 10.1016/j.acuro.2013.04.008 \| PMID = 24129226 }}</ref>

			===Classification===
			It can be classified into:<ref name=pmid20815946>{{Cite journal \| last1 = Billis \| first1 = A. \| title = Prostatic atrophy. Clinicopathological significance. \| journal = Int Braz J Urol \| volume = 36 \| issue = 4 \| pages = 401-9 \| month = \| year = \| doi = \| PMID = 20815946 }}</ref>
			#Focal prostatic atrophy.
			#Diffuse prostatic atrophy.

			Focal atrophy can be subclassified as:<ref name=pmid20815946/>
			#Partial.
			#Complete.
			#Combined.

	==Microscopic==		==Microscopic==

Michael: /* Sign out */

2015-01-20T00:11:33Z

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	Generally, this finding is ''not'' reported; it is considered a normal finding.		Generally, this finding is ''not'' reported; it is considered a normal finding.

			<pre>
			Left Apex:
			- Benign prostate tissue with glandular atrophy.
			</pre>

	===Micro===		===Micro===

Michael at 19:13, 6 May 2014

2014-05-06T19:13:15Z

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	*[http://webpathology.com/image.asp?case=16&n=5 Partial atrophy (webpathology.com)].		*[http://webpathology.com/image.asp?case=16&n=5 Partial atrophy (webpathology.com)].
	*[http://webpathology.com/image.asp?case=16&n=6 Sclerotic atrophy (webpathology.com)].		*[http://webpathology.com/image.asp?case=16&n=6 Sclerotic atrophy (webpathology.com)].

			==IHC==
			*Classically like normal prostate (AMACR -ve, p63 +ve, CK34betaE12 +ve).
			**May be negative for basal cell markers, i.e. p63 and CK34betaE12.<ref name=pmid18408595>{{cite journal \|author=Wang W, Sun X, Epstein JI \|title=Partial atrophy on prostate needle biopsy cores: a morphologic and immunohistochemical study \|journal=Am. J. Surg. Pathol. \|volume=32 \|issue=6 \|pages=851–7 \|year=2008 \|month=June \|pmid=18408595 \|doi=10.1097/PAS.0b013e31815a0508 \|url=}}</ref>

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Michael: /* Sign out */

2014-05-06T19:10:25Z

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	Generally, this finding is ''not'' reported; it is considered a normal finding.		Generally, this finding is ''not'' reported; it is considered a normal finding.

			===Micro===
			The core shows rare, spaced, atrophic appearing glands, mostly with a wavy border and a decreased quantity of cytoplasm. Prominent nucleoli and significant nuclear enlargement are not identified.

			There are none of the following: mitoses, adjacent PIN, suspicious luminal material, nuclear hyperchromasia.

	==See also==		==See also==

Michael at 05:17, 29 April 2014

2014-04-29T05:17:01Z

← Older revision		Revision as of 05:17, 29 April 2014
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	\| Caption = Atrophic prostatic glands. [[H&E stain]].		\| Caption = Atrophic prostatic glands. [[H&E stain]].
	\| Synonyms =		\| Synonyms =
	\| Micro =		\| Micro = glands typically have a jagged edges/prows (in cancer the glands tend to have round edges), gland density is usually lower than in prostate carcinoma (glands are not back-to-back), nuclei small & hyperchromatic, scant cytoplasm
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[prostate carcinoma]] - esp. [[atrophic prostate carcinoma]], [[atypical small acinar proliferation]]		\| LMDDx = [[prostate carcinoma]] - esp. [[atrophic prostate carcinoma]], [[atypical small acinar proliferation]]

Michael: /* Images */ fix

2014-04-29T05:06:35Z

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	===Images===		===Images===
	<gallery>		<gallery>
	Image: Atrophic prostatic glands -- low mag.jpg \| APG - low mag.		Image: Atrophic prostatic glands -- low mag.jpg \| APG - low mag. (WC)
	Image: Atrophic prostatic glands -- intermed mag.jpg \| APG - intermed. mag.		Image: Atrophic prostatic glands -- intermed mag.jpg \| APG - intermed. mag. (WC)
	Image: Atrophic prostatic glands -- high mag.jpg \| APG - high mag.		Image: Atrophic prostatic glands -- high mag.jpg \| APG - high mag. (WC)
	~~<!--~~ Image: Atrophic prostatic glands -- very high mag.jpg \| APG - very high mag. ~~-->~~		Image: Atrophic prostatic glands -- very high mag.jpg \| APG - very high mag. (WC)
	</gallery>		</gallery>
	www:		www:

Michael: /* Images */

2014-04-29T05:06:08Z

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	===Images===		===Images===
	<gallery>		<gallery>
	~~<!--~~ Image: Atrophic prostatic glands -- low mag.jpg \| APG - low mag. ~~-->~~		Image: Atrophic prostatic glands -- low mag.jpg \| APG - low mag.
	Image: Atrophic prostatic glands -- intermed mag.jpg \| APG - intermed. mag.		Image: Atrophic prostatic glands -- intermed mag.jpg \| APG - intermed. mag.
	Image: Atrophic prostatic glands -- high mag.jpg \| APG - high mag.		Image: Atrophic prostatic glands -- high mag.jpg \| APG - high mag.

Michael: /* Images */

2014-04-29T04:51:48Z

Images

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	<!-- Image: Atrophic prostatic glands -- low mag.jpg \| APG - low mag. -->		<!-- Image: Atrophic prostatic glands -- low mag.jpg \| APG - low mag. -->
	Image: Atrophic prostatic glands -- intermed mag.jpg \| APG - intermed. mag.		Image: Atrophic prostatic glands -- intermed mag.jpg \| APG - intermed. mag.
	~~<!--~~ Image: Atrophic prostatic glands -- high mag.jpg \| APG - high mag. ~~-->~~		Image: Atrophic prostatic glands -- high mag.jpg \| APG - high mag.
	<!-- Image: Atrophic prostatic glands -- very high mag.jpg \| APG - very high mag. -->		<!-- Image: Atrophic prostatic glands -- very high mag.jpg \| APG - very high mag. -->
	</gallery>		</gallery>
			www:
			*[http://webpathology.com/image.asp?case=16&n=7 Atrophy (webpathology.com)].
			*[http://webpathology.com/image.asp?case=16&n=5 Partial atrophy (webpathology.com)].
			*[http://webpathology.com/image.asp?case=16&n=6 Sclerotic atrophy (webpathology.com)].

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Michael: /* Images */

2014-04-29T04:47:56Z

Images

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	<!-- Image: Atrophic prostatic glands -- low mag.jpg \| APG - low mag. -->		<!-- Image: Atrophic prostatic glands -- low mag.jpg \| APG - low mag. -->
	Image: Atrophic prostatic glands -- intermed mag.jpg \| APG - intermed. mag.		Image: Atrophic prostatic glands -- intermed mag.jpg \| APG - intermed. mag.
	<!-- Image: Atrophic prostatic glands -- high mag.jpg \| APG - high mag.		<!-- Image: Atrophic prostatic glands -- high mag.jpg \| APG - high mag. -->
	Image: Atrophic prostatic glands -- very high mag.jpg \| APG - very high mag. -->		<!-- Image: Atrophic prostatic glands -- very high mag.jpg \| APG - very high mag. -->
	</gallery>		</gallery>

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	<!-- Image: Atrophic prostatic glands -- low mag.jpg \| APG - low mag. -->		<!-- Image: Atrophic prostatic glands -- low mag.jpg \| APG - low mag. -->
	Image: Atrophic prostatic glands -- intermed mag.jpg \| APG - intermed. mag.		Image: Atrophic prostatic glands -- intermed mag.jpg \| APG - intermed. mag.
	<!-- Image: Atrophic prostatic glands -- high mag.jpg \| APG - high mag.		<!-- Image: Atrophic prostatic glands -- high mag.jpg \| APG - high mag. -->
	Image: Atrophic prostatic glands -- very high mag.jpg \| APG - very high mag. -->		<!-- Image: Atrophic prostatic glands -- very high mag.jpg \| APG - very high mag. -->
	</gallery>		</gallery>