Angiomyolipoma - Revision history

Michael: /* Sign out */

2025-02-26T16:27:37Z

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← Older revision		Revision as of 16:27, 26 February 2025
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	NEGATIVE: CK (pooled).		NEGATIVE: CK (pooled).
	</pre>		</pre>

			=====Micro=====
			The sections show a tumour composed of spindle cells in a fascicular arrangement with scant adipose tissue and prominent muscular blood vessels. Rare nuclear enlargement is seen. No significant nuclear atypia is appreciated. Mitotic activity is not apparent. No renal parenchyma is identified.

			===Epithelioid===
			Comment:
			Epithelioid change in angiomyolipoma can be associated with aggressive behaviour; follow-up is recommended.

	====Micro====		====Micro====
	The sections show a tumour composed of spindle cells in a fascicular arrangement with ~~scant~~ adipose tissue and prominent muscular blood vessels. ~~Rare nuclear enlargement~~ is ~~seen. No significant nuclear~~ atypia ~~is appreciated~~. Mitotic activity is not apparent. ~~No renal parenchyma~~ is ~~identified~~.		The sections show a tumour composed of spindle cells in a fascicular arrangement with abundant adipose tissue and prominent muscular blood vessels. A focal epithelioid subcomponent is present and has moderate atypia. Mitotic activity is not readily apparent. The epithelioid component is completely removed in the plane-of-section.

	==See also==		==See also==

Michael: fix typo

2024-11-28T21:58:08Z

fix typo

← Older revision		Revision as of 21:58, 28 November 2024
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	====Micro====		====Micro====
	The section show a circumscribed tumour composed of muscle-like tissue and adipose tissue with prominent muscular blood vessels. Rare nuclear enlargement is seen. No ~~signficant~~ nuclear atypia is appreciated. Mitotic activity is not apparent.		The section show a circumscribed tumour composed of muscle-like tissue and adipose tissue with prominent muscular blood vessels. Rare nuclear enlargement is seen. No significant nuclear atypia is appreciated. Mitotic activity is not apparent.

	===Biopsy===		===Biopsy===

Michael: +may involve LNs

2023-03-31T15:08:40Z

+may involve LNs

← Older revision		Revision as of 15:08, 31 March 2023
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	*Abundant [[blood vessel]]s.		*Abundant [[blood vessel]]s.

	~~Note~~:		Notes:
	*May have melanin pigment - occasionally extensive.<ref name=pmid26118214>{{Cite journal \| last1 = Reddy \| first1 = R. \| last2 = Lewin \| first2 = JR. \| last3 = Shenoy \| first3 = V. \| title = Pigmented Epithelioid Angiomyolipoma of the Kidney. \| journal = J Miss State Med Assoc \| volume = 56 \| issue = 4 \| pages = 92-4 \| month = Apr \| year = 2015 \| doi = \| PMID = 26118214 }}</ref><ref name=pmid23136579>{{Cite journal \| last1 = Chang \| first1 = H. \| last2 = Jung \| first2 = W. \| last3 = Kang \| first3 = Y. \| last4 = Jung \| first4 = WY. \| title = Pigmented perivascular epithelioid cell tumor (PEComa) of the kidney: a case report and review of the literature. \| journal = Korean J Pathol \| volume = 46 \| issue = 5 \| pages = 499-502 \| month = Oct \| year = 2012 \| doi = 10.4132/KoreanJPathol.2012.46.5.499 \| PMID = 23136579 }}</ref>		*May have melanin pigment - occasionally extensive.<ref name=pmid26118214>{{Cite journal \| last1 = Reddy \| first1 = R. \| last2 = Lewin \| first2 = JR. \| last3 = Shenoy \| first3 = V. \| title = Pigmented Epithelioid Angiomyolipoma of the Kidney. \| journal = J Miss State Med Assoc \| volume = 56 \| issue = 4 \| pages = 92-4 \| month = Apr \| year = 2015 \| doi = \| PMID = 26118214 }}</ref><ref name=pmid23136579>{{Cite journal \| last1 = Chang \| first1 = H. \| last2 = Jung \| first2 = W. \| last3 = Kang \| first3 = Y. \| last4 = Jung \| first4 = WY. \| title = Pigmented perivascular epithelioid cell tumor (PEComa) of the kidney: a case report and review of the literature. \| journal = Korean J Pathol \| volume = 46 \| issue = 5 \| pages = 499-502 \| month = Oct \| year = 2012 \| doi = 10.4132/KoreanJPathol.2012.46.5.499 \| PMID = 23136579 }}</ref>
			*May involve lymph nodes - case reports.<ref name=pmid2294869>{{cite journal \|authors=Ro JY, Ayala AG, el-Naggar A, Grignon DJ, Hogan SF, Howard DR \|title=Angiomyolipoma of kidney with lymph node involvement. DNA flow cytometric analysis \|journal=Arch Pathol Lab Med \|volume=114 \|issue=1 \|pages=65–7 \|date=January 1990 \|pmid=2294869 \|doi= \|url=}}</ref><ref name=pmid12696187>{{cite journal \|vauthor=Shiga Y, Tsutsumi M, Suzuki K, Ishikawa S, Shimogama T \|title=Angiomyolipoma with regional lymph node involvement: a case report and literature review \|journal=Hinyokika Kiyo \|volume=49 \|issue=2 \|pages=81–6 \|date=February 2003 \|pmid=12696187 \|doi= \|url=}}</ref>

	DDx:		DDx:

Michael: /* Micro */ fix sp

2019-12-09T15:56:55Z

Micro: fix sp

← Older revision		Revision as of 15:56, 9 December 2019
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	====Micro====		====Micro====
	The sections show a tumour composed of spindle cells in a ~~fasicular~~ arrangement with scant adipose tissue and prominent muscular blood vessels. Rare nuclear enlargement is seen. No significant nuclear atypia is appreciated. Mitotic activity is not apparent. No renal parenchyma is identified.		The sections show a tumour composed of spindle cells in a fascicular arrangement with scant adipose tissue and prominent muscular blood vessels. Rare nuclear enlargement is seen. No significant nuclear atypia is appreciated. Mitotic activity is not apparent. No renal parenchyma is identified.

	==See also==		==See also==

Michael: /* Micro */

2019-12-09T15:54:05Z

Micro

← Older revision		Revision as of 15:54, 9 December 2019
Line 208:		Line 208:

	====Micro====		====Micro====
	The sections show a tumour composed of spindle cells in a fasicular arrangement with scant adipose tissue and prominent muscular blood vessels. Rare nuclear enlargement is seen. No ~~signficant~~ nuclear atypia is appreciated. Mitotic activity is not apparent. No renal parenchyma is identified.		The sections show a tumour composed of spindle cells in a fasicular arrangement with scant adipose tissue and prominent muscular blood vessels. Rare nuclear enlargement is seen. No significant nuclear atypia is appreciated. Mitotic activity is not apparent. No renal parenchyma is identified.

	==See also==		==See also==

Michael: /* Biopsy */

2019-12-09T15:52:30Z

Biopsy

← Older revision		Revision as of 15:52, 9 December 2019
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	===Biopsy===		===Biopsy===
			<pre>
			Left Kidney, Mass Lesion, Core Biopsy:
			- Angiomyolipoma, see comment.

			Comment:
			The tumour stains as follow:
			POSITIVE: melan A (focal, rare).
			NEGATIVE: PAX8, AE1/AE3, HMB-45, desmin, PR, ER.
			</pre>

			====Alternate====
	<pre>		<pre>
	MASS OF LEFT KIDNEY, CORE BIOPSY:		MASS OF LEFT KIDNEY, CORE BIOPSY:

Michael: /* Epithelioid angiomyolipoma */

2017-01-25T21:20:24Z

Epithelioid angiomyolipoma

← Older revision		Revision as of 21:20, 25 January 2017
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	DDx:		DDx:
	*[[Clear cell renal cell carcinoma]] ~~eosinophilic variant - esp. if epithelioid~~.		*[[Clear cell renal cell carcinoma]].
	*[[Xp11.2 translocation carcinoma]].		*[[Xp11.2 translocation carcinoma]].
	*Renal cell carcinoma with angioleiomyoma-like stroma.<ref name=pmid25189644>{{Cite journal \| last1 = Williamson \| first1 = SR. \| last2 = Cheng \| first2 = L. \| last3 = Eble \| first3 = JN. \| last4 = True \| first4 = LD. \| last5 = Gupta \| first5 = NS. \| last6 = Wang \| first6 = M. \| last7 = Zhang \| first7 = S. \| last8 = Grignon \| first8 = DJ. \| title = Renal cell carcinoma with angioleiomyoma-like stroma: clinicopathological, immunohistochemical, and molecular features supporting classification as a distinct entity. \| journal = Mod Pathol \| volume = \| issue = \| pages = \| month = Sep \| year = 2014 \| doi = 10.1038/modpathol.2014.105 \| PMID = 25189644 }}</ref>		*Renal cell carcinoma with angioleiomyoma-like stroma.<ref name=pmid25189644>{{Cite journal \| last1 = Williamson \| first1 = SR. \| last2 = Cheng \| first2 = L. \| last3 = Eble \| first3 = JN. \| last4 = True \| first4 = LD. \| last5 = Gupta \| first5 = NS. \| last6 = Wang \| first6 = M. \| last7 = Zhang \| first7 = S. \| last8 = Grignon \| first8 = DJ. \| title = Renal cell carcinoma with angioleiomyoma-like stroma: clinicopathological, immunohistochemical, and molecular features supporting classification as a distinct entity. \| journal = Mod Pathol \| volume = \| issue = \| pages = \| month = Sep \| year = 2014 \| doi = 10.1038/modpathol.2014.105 \| PMID = 25189644 }}</ref>

Michael: /* Microscopic */

2017-01-25T21:19:48Z

Microscopic

← Older revision		Revision as of 21:19, 25 January 2017
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	Note:		Note:
	*May have melanin pigment.<ref name=pmid26118214>{{Cite journal \| last1 = Reddy \| first1 = R. \| last2 = Lewin \| first2 = JR. \| last3 = Shenoy \| first3 = V. \| title = Pigmented Epithelioid Angiomyolipoma of the Kidney. \| journal = J Miss State Med Assoc \| volume = 56 \| issue = 4 \| pages = 92-4 \| month = Apr \| year = 2015 \| doi = \| PMID = 26118214 }}</ref>		*May have melanin pigment - occasionally extensive.<ref name=pmid26118214>{{Cite journal \| last1 = Reddy \| first1 = R. \| last2 = Lewin \| first2 = JR. \| last3 = Shenoy \| first3 = V. \| title = Pigmented Epithelioid Angiomyolipoma of the Kidney. \| journal = J Miss State Med Assoc \| volume = 56 \| issue = 4 \| pages = 92-4 \| month = Apr \| year = 2015 \| doi = \| PMID = 26118214 }}</ref><ref name=pmid23136579>{{Cite journal \| last1 = Chang \| first1 = H. \| last2 = Jung \| first2 = W. \| last3 = Kang \| first3 = Y. \| last4 = Jung \| first4 = WY. \| title = Pigmented perivascular epithelioid cell tumor (PEComa) of the kidney: a case report and review of the literature. \| journal = Korean J Pathol \| volume = 46 \| issue = 5 \| pages = 499-502 \| month = Oct \| year = 2012 \| doi = 10.4132/KoreanJPathol.2012.46.5.499 \| PMID = 23136579 }}</ref>

	DDx:		DDx:

Michael: /* Microscopic */

2017-01-25T21:18:13Z

Microscopic

← Older revision		Revision as of 21:18, 25 January 2017
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	*Adipose tissue - not always present<ref name=pmid15584043>{{Cite journal \| last1 = Crapanzano \| first1 = JP. \| title = Fine-needle aspiration of renal angiomyolipoma: cytological findings and diagnostic pitfalls in a series of five cases. \| journal = Diagn Cytopathol \| volume = 32 \| issue = 1 \| pages = 53-7 \| month = Jan \| year = 2005 \| doi = 10.1002/dc.20179 \| PMID = 15584043 }}</ref> - '''key feature'''.		*Adipose tissue - not always present<ref name=pmid15584043>{{Cite journal \| last1 = Crapanzano \| first1 = JP. \| title = Fine-needle aspiration of renal angiomyolipoma: cytological findings and diagnostic pitfalls in a series of five cases. \| journal = Diagn Cytopathol \| volume = 32 \| issue = 1 \| pages = 53-7 \| month = Jan \| year = 2005 \| doi = 10.1002/dc.20179 \| PMID = 15584043 }}</ref> - '''key feature'''.
	*Abundant [[blood vessel]]s.		*Abundant [[blood vessel]]s.

			Note:
			*May have melanin pigment.<ref name=pmid26118214>{{Cite journal \| last1 = Reddy \| first1 = R. \| last2 = Lewin \| first2 = JR. \| last3 = Shenoy \| first3 = V. \| title = Pigmented Epithelioid Angiomyolipoma of the Kidney. \| journal = J Miss State Med Assoc \| volume = 56 \| issue = 4 \| pages = 92-4 \| month = Apr \| year = 2015 \| doi = \| PMID = 26118214 }}</ref>

	DDx:		DDx:

Michael: /* Related images */

2017-01-18T05:45:36Z

Related images

← Older revision		Revision as of 05:45, 18 January 2017
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	====Images====		====Images====
	~~==Related images==~~
	<gallery>		<gallery>
	Image: Epithelioid angiomyolipoma -- very low mag.jpg \| EMAL - very low mag.		Image: Epithelioid angiomyolipoma -- very low mag.jpg \| EMAL - very low mag.