Angiomatoid fibrous histiocytoma - Revision history

Michael at 02:53, 22 June 2014

2014-06-22T02:53:49Z

← Older revision		Revision as of 02:53, 22 June 2014
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	===Images===		===Images===
	<gallery>		<gallery>
	Image:~~Angiomatoid_fibrous_histiocytoma_~~-~~_intermed_mag~~.jpg \| AFH - intermed. mag. ~~(WC/Nephron)~~		Image: Angiomatoid fibrous histiocytoma - low mag.jpg \| AFH - low mag.
	Image:~~Angiomatoid_fibrous_histiocytoma_~~-~~_high_mag~~.jpg \| AFH - high mag. ~~(WC/Nephron)~~		Image: Angiomatoid fibrous histiocytoma - intermed mag.jpg \| AFH - intermed. mag.
			Image: Angiomatoid fibrous histiocytoma - high mag.jpg \| AFH - high mag.
			Image: Angiomatoid fibrous histiocytoma - very high mag.jpg \| AFH - very high mag.

			Image: Angiomatoid fibrous histiocytoma - intermed mag - 2.jpg \| AFH - intermed. mag.
			Image: Angiomatoid fibrous histiocytoma - high mag - 2.jpg \| AFH - high mag.
			Image: Angiomatoid fibrous histiocytoma - very high mag - 2.jpg \| AFH - very high mag.
	</gallery>		</gallery>
	www:		www:

Michael at 02:52, 22 June 2014

2014-06-22T02:52:21Z

← Older revision		Revision as of 02:52, 22 June 2014
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Angiomatoid_fibrous_histiocytoma_-_intermed_mag.jpg
			\| Width =
			\| Caption = Angiomatoid fibrous histiocytoma. [[H&E stain]].
			\| Synonyms =
			\| Micro = cystic spaces with blood +/- histiocytic appearance; inflammation (lymphocytes around periphery of lesion); hemorrhage
			\| Subtypes =
			\| LMDDx =
			\| Stains =
			\| IHC = CD68 +ve, CD57 +ve, desmin +ve (focal), vimentin +ve
			\| EM =
			\| Molecular = t(12;16) FUS/ATF1, t(12;22) EWS/ATF1, others
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[soft tissue lesions\|soft tissue]] - usu. extremities
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx = children, young adults
			\| Signs =
			\| Symptoms =
			\| Prevalence = uncommon
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = usually good
			\| Other =
			\| ClinDDx =
			\| Tx = complete excision
			}}
	'''Angiomatoid fibrous histiocytoma''', abbreviated '''AFH''', is a rare [[soft tissue lesion]] that is typically seen in children and young adults.		'''Angiomatoid fibrous histiocytoma''', abbreviated '''AFH''', is a rare [[soft tissue lesion]] that is typically seen in children and young adults.

Michael: /* General */

2014-06-21T11:47:50Z

General

← Older revision		Revision as of 11:47, 21 June 2014
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	*Rarely metastasizes.		*Rarely metastasizes.
	*Children & young adults.		*Children & young adults.
			*Should be completely excised.

			==Gross==
			*Usu. soft tissue of the extremities.{{fact}}

	==Microscopic==		==Microscopic==

Michael: /* IHC */

2014-06-21T11:45:16Z

IHC

← Older revision		Revision as of 11:45, 21 June 2014
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	*CD68 +ve.		*CD68 +ve.
	*CD57 +ve.		*CD57 +ve.
	*Desmin +ve.		*Desmin +ve (focal).
	*Vimentin +ve.		*Vimentin +ve.

Michael at 04:08, 3 June 2014

2014-06-03T04:08:27Z

← Older revision		Revision as of 04:08, 3 June 2014
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	'''Angiomatoid fibrous histiocytoma''' is a rare [[soft tissue lesion]] that is typically seen in children and young adults.		'''Angiomatoid fibrous histiocytoma''', abbreviated '''AFH''', is a rare [[soft tissue lesion]] that is typically seen in children and young adults.

	==General==		==General==

Michael: split out

2014-06-03T04:05:44Z

split out

← Older revision		Revision as of 04:05, 3 June 2014
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	~~#redirect~~ [[~~Soft_tissue_lesions#Angiomatoid_fibrous_histiocytoma~~]]		'''Angiomatoid fibrous histiocytoma''' is a rare [[soft tissue lesion]] that is typically seen in children and young adults.

			==General==
			*Rarely metastasizes.
			*Children & young adults.

			==Microscopic==
			Features:<ref name=Ref_WMSP624-5>{{Ref WMSP\|624-5}}</ref>
			*Cystic spaces with blood - simulates a vascular neoplasm.<ref name=pmid228836>{{Cite journal \| last1 = Enzinger \| first1 = FM. \| title = Angiomatoid malignant fibrous histiocytoma: a distinct fibrohistiocytic tumor of children and young adults simulating a vascular neoplasm. \| journal = Cancer \| volume = 44 \| issue = 6 \| pages = 2147-57 \| month = Dec \| year = 1979 \| doi = \| PMID = 228836 }}</ref>
			*Epithelioid to spindle cells.
			**May have a histiocytic appearance.<ref>URL: [http://dermatology.cdlib.org/1605/1_case_reports/4_09-00041/patrizi.html http://dermatology.cdlib.org/1605/1_case_reports/4_09-00041/patrizi.html]. Accessed on: 15 November 2011.</ref>
			*Inflammation.
			**Lymphoid cuff<ref name=pmid20154033/> - lymphocytes around periphery of lesion.
			*Hemorrhage.

			Note:
			*The first impression may be that it is [[granuloma\|granulomatous inflammation]]; however, the cytoplasm doesn't fit (it isn't bubbly and it isn't sheet-like), and the nuclei aren't quite right (few footprint shaped nuclei).

			===Images===
			<gallery>
			Image:Angiomatoid_fibrous_histiocytoma_-_intermed_mag.jpg \| AFH - intermed. mag. (WC/Nephron)
			Image:Angiomatoid_fibrous_histiocytoma_-_high_mag.jpg \| AFH - high mag. (WC/Nephron)
			</gallery>
			www:
			*[http://www.sarcomaimages.com/index.php?v=Angiomatoid-Fibrous-Histiocytoma AFH (sarcomaimages.com)].
			*[http://jcp.bmj.com/content/63/2/124/F1.large.jpg AFH (bmj.com)].<ref name=pmid20154033>{{Cite journal \| last1 = Matsumura \| first1 = T. \| last2 = Yamaguchi \| first2 = T. \| last3 = Tochigi \| first3 = N. \| last4 = Wada \| first4 = T. \| last5 = Yamashita \| first5 = T. \| last6 = Hasegawa \| first6 = T. \| title = Angiomatoid fibrous histiocytoma including cases with pleomorphic features analysed by fluorescence in situ hybridisation. \| journal = J Clin Pathol \| volume = 63 \| issue = 2 \| pages = 124-8 \| month = Feb \| year = 2010 \| doi = 10.1136/jcp.2009.072256 \| PMID = 20154033 \| url = http://jcp.bmj.com/content/63/2/124.full }}
			</ref>
			*[http://path.upmc.edu/cases/case512.html AFH - several images (upmc.edu)].

			==IHC==
			Features:<ref name=Ref_WMSP624-5>{{Ref WMSP\|624-5}}</ref>
			*CD68 +ve.
			*CD57 +ve.
			*Desmin +ve.
			*Vimentin +ve.

			==Molecular==
			AFH has recurrent [[translocations]]:
			*t(12;16) FUS/ATF1.
			*t(12;22) EWS/ATF1.

			==See also==
			*[[Soft tissue lesions]].

			==References==
			{{Reflist\|2}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Soft tissue lesions]]
			[[Category:Pediatric pathology]]

Michael: +cat.

2011-10-20T05:09:46Z

+cat.

← Older revision		Revision as of 05:09, 20 October 2011
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	#redirect [[Soft_tissue_lesions#Angiomatoid_fibrous_histiocytoma]]		#redirect [[Soft_tissue_lesions#Angiomatoid_fibrous_histiocytoma]]

			[[Category:Diagnosis]]

Michael: redirect

2011-09-07T16:42:46Z

redirect

New page

#redirect [[Soft_tissue_lesions#Angiomatoid_fibrous_histiocytoma]]