Anal squamous cell carcinoma - Revision history

Michael: more

2023-06-26T16:25:45Z

← Older revision		Revision as of 16:25, 26 June 2023
Line 9:		Line 9:
	\| LMDDx = [[anal intraepithelial neoplasia]], poorly differentiated [[rectal adenocarcinoma]], [[anal gland adenocarcinoma]]		\| LMDDx = [[anal intraepithelial neoplasia]], poorly differentiated [[rectal adenocarcinoma]], [[anal gland adenocarcinoma]]
	\| Stains =		\| Stains =
	\| IHC =		\| IHC = p16 +ve
	\| EM =		\| EM =
	\| Molecular =		\| Molecular = HPV +ve
	\| IF =		\| IF =
	\| Gross =		\| Gross =
Line 74:		Line 74:
	</pre>		</pre>

	~~Note~~:		Notes:
	*There is no CAP Cancer Protocol Template.		*There is no CAP Cancer Protocol Template.
	*AJCC staging is based on size of the tumour.<ref>URL: [https://www.cancer.org/cancer/types/anal-cancer/detection-diagnosis-staging/staging.html https://www.cancer.org/cancer/types/anal-cancer/detection-diagnosis-staging/staging.html]. Accessed on: June 26, 2023.</ref>		*AJCC staging is based on size of the tumour.<ref>URL: [https://www.cancer.org/cancer/types/anal-cancer/detection-diagnosis-staging/staging.html https://www.cancer.org/cancer/types/anal-cancer/detection-diagnosis-staging/staging.html]. Accessed on: June 26, 2023.</ref>

Michael: more

2023-06-26T16:24:24Z

← Older revision		Revision as of 16:24, 26 June 2023
Line 65:		Line 65:
	*CDX2 -ve/+ve.		*CDX2 -ve/+ve.
	**May be useful to differentiate from [[vulva]] and [[penis]].<ref name=pmid23105122>{{Cite journal \| last1 = Gunia \| first1 = S. \| last2 = Koch \| first2 = S. \| last3 = May \| first3 = M. \| title = Is CDX2 immunostaining useful for delineating anorectal from penile/vulvar squamous cancer in the setting of squamous cell carcinoma with clinically unknown primary site presenting with histologically confirmed inguinal lymph node metastasis? \| journal = J Clin Pathol \| volume = 66 \| issue = 2 \| pages = 109-12 \| month = Feb \| year = 2013 \| doi = 10.1136/jclinpath-2012-201138 \| PMID = 23105122 }}</ref>		**May be useful to differentiate from [[vulva]] and [[penis]].<ref name=pmid23105122>{{Cite journal \| last1 = Gunia \| first1 = S. \| last2 = Koch \| first2 = S. \| last3 = May \| first3 = M. \| title = Is CDX2 immunostaining useful for delineating anorectal from penile/vulvar squamous cancer in the setting of squamous cell carcinoma with clinically unknown primary site presenting with histologically confirmed inguinal lymph node metastasis? \| journal = J Clin Pathol \| volume = 66 \| issue = 2 \| pages = 109-12 \| month = Feb \| year = 2013 \| doi = 10.1136/jclinpath-2012-201138 \| PMID = 23105122 }}</ref>
			*PD-L1 +ve in ~40% of cases.<ref name=pmid34790403>{{cite journal \|authors=Armstrong SA, Malley R, Wang H, Lenz HJ, Arguello D, El-Deiry WS, Xiu J, Gatalica Z, Hwang JJ, Philip PA, Shields AF, Marshall JL, Salem ME, Weinberg BA \|title=Molecular characterization of squamous cell carcinoma of the anal canal \|journal=J Gastrointest Oncol \|volume=12 \|issue=5 \|pages=2423–2437 \|date=October 2021 \|pmid=34790403 \|pmc=8576238 \|doi=10.21037/jgo-20-610 \|url=}}</ref>
			**PD-1 expressed in nearly 70% of tumours.<ref name=pmid34790403/>

	==Sign out==		==Sign out==
Line 71:		Line 73:
	- INVASIVE SQUAMOUS CELL CARCINOMA.		- INVASIVE SQUAMOUS CELL CARCINOMA.
	</pre>		</pre>

			Note:
			*There is no CAP Cancer Protocol Template.
			*AJCC staging is based on size of the tumour.<ref>URL: [https://www.cancer.org/cancer/types/anal-cancer/detection-diagnosis-staging/staging.html https://www.cancer.org/cancer/types/anal-cancer/detection-diagnosis-staging/staging.html]. Accessed on: June 26, 2023.</ref>

	==See also==		==See also==

Michael: /* Microscopic */

2015-03-19T18:15:45Z

Microscopic

← Older revision		Revision as of 18:15, 19 March 2015
Line 50:		Line 50:
	DDx:		DDx:
	*[[Anal intraepithelial neoplasia]].		*[[Anal intraepithelial neoplasia]].
			*Rectal squamous cell carcinoma.<ref name=pmid17661147>{{Cite journal \| last1 = Nahas \| first1 = CS. \| last2 = Shia \| first2 = J. \| last3 = Joseph \| first3 = R. \| last4 = Schrag \| first4 = D. \| last5 = Minsky \| first5 = BD. \| last6 = Weiser \| first6 = MR. \| last7 = Guillem \| first7 = JG. \| last8 = Paty \| first8 = PB. \| last9 = Klimstra \| first9 = DS. \| title = Squamous-cell carcinoma of the rectum: a rare but curable tumor. \| journal = Dis Colon Rectum \| volume = 50 \| issue = 9 \| pages = 1393-400 \| month = Sep \| year = 2007 \| doi = 10.1007/s10350-007-0256-z \| PMID = 17661147 }}</ref>
	*Poorly differentiated [[rectal adenocarcinoma]].		*Poorly differentiated [[rectal adenocarcinoma]].
	*[[Anal gland adenocarcinoma]].		*[[Anal gland adenocarcinoma]].

Michael at 18:12, 19 March 2015

2015-03-19T18:12:39Z

← Older revision		Revision as of 18:12, 19 March 2015
Line 7:		Line 7:
	\| Micro =		\| Micro =
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[anal intraepithelial neoplasia]]		\| LMDDx = [[anal intraepithelial neoplasia]], poorly differentiated [[rectal adenocarcinoma]], [[anal gland adenocarcinoma]]
	\| Stains =		\| Stains =
	\| IHC =		\| IHC =

Michael: /* Microscopic */

2015-03-19T18:12:22Z

Microscopic

← Older revision		Revision as of 18:12, 19 March 2015
Line 50:		Line 50:
	DDx:		DDx:
	*[[Anal intraepithelial neoplasia]].		*[[Anal intraepithelial neoplasia]].
			*Poorly differentiated [[rectal adenocarcinoma]].
	*[[Anal gland adenocarcinoma]].		*[[Anal gland adenocarcinoma]].
	*Poorly differentiated [[rectal adenocarcinoma]].

	===Images===		===Images===

Michael at 18:10, 19 March 2015

2015-03-19T18:10:27Z

← Older revision		Revision as of 18:10, 19 March 2015
Line 50:		Line 50:
	DDx:		DDx:
	*[[Anal intraepithelial neoplasia]].		*[[Anal intraepithelial neoplasia]].
			*[[Anal gland adenocarcinoma]].
			*Poorly differentiated [[rectal adenocarcinoma]].

	===Images===		===Images===
Line 57:		Line 59:
	Image:Anus SquamousCellCarcinoma SCC NonKeratinizing MP4 CTR.jpg\|Anus Squamous Cell Carcinoma (Non Keratinizing or shall we say poorly keratinizing as there are squamatized nests focally at high power) - (SKB)		Image:Anus SquamousCellCarcinoma SCC NonKeratinizing MP4 CTR.jpg\|Anus Squamous Cell Carcinoma (Non Keratinizing or shall we say poorly keratinizing as there are squamatized nests focally at high power) - (SKB)
	</gallery>		</gallery>
	~~DDx:~~
	*[[Anal gland adenocarcinoma]].
	*Poorly differentiated [[rectal adenocarcinoma]].

	==IHC==		==IHC==

Michael at 18:09, 19 March 2015

2015-03-19T18:09:48Z

← Older revision		Revision as of 18:09, 19 March 2015
Line 7:		Line 7:
	\| Micro =		\| Micro =
	\| Subtypes =		\| Subtypes =
	\| LMDDx =		\| LMDDx = [[anal intraepithelial neoplasia]]
	\| Stains =		\| Stains =
	\| IHC =		\| IHC =
Line 48:		Line 48:
	*See ''[[squamous cell carcinoma]]''.		*See ''[[squamous cell carcinoma]]''.

			DDx:
			*[[Anal intraepithelial neoplasia]].

			===Images===
	<gallery>		<gallery>
	Image:Anus SquamousCellCarcinoma SCC NonKeratinizing AIA SCCIS CTR.jpg\|Anus Squamous Cell Carcinoma (Non Keratinizing) - (SKB)		Image:Anus SquamousCellCarcinoma SCC NonKeratinizing AIA SCCIS CTR.jpg\|Anus Squamous Cell Carcinoma (Non Keratinizing) - (SKB)

Michael at 18:07, 19 March 2015

2015-03-19T18:07:04Z

← Older revision		Revision as of 18:07, 19 March 2015
Line 1:		Line 1:
			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Anus SquamousCellCarcinoma SCC NonKeratinizing AIA SCCIS CTR.jpg
			\| Width =
			\| Caption = Anal squamous cell carcinoma. [[H&E stain]].
			\| Synonyms =
			\| Micro =
			\| Subtypes =
			\| LMDDx =
			\| Stains =
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[anus]]
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx = +/-men who have sex with men, +/-immunodeficiency or immunosuppression
			\| Signs =
			\| Symptoms =
			\| Prevalence = most common anal cancer, overall uncommon
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis =
			\| Other =
			\| ClinDDx =
			\| Tx = surgical excision
			}}
	'''Anal squamous cell carcinoma''' is the most common type of [[anal cancer]].<ref name=pmid25741135>{{Cite journal \| last1 = Ghosn \| first1 = M. \| last2 = Kourie \| first2 = HR. \| last3 = Abdayem \| first3 = P. \| last4 = Antoun \| first4 = J. \| last5 = Nasr \| first5 = D. \| title = Anal cancer treatment: Current status and future perspectives. \| journal = World J Gastroenterol \| volume = 21 \| issue = 8 \| pages = 2294-2302 \| month = Feb \| year = 2015 \| doi = 10.3748/wjg.v21.i8.2294 \| PMID = 25741135 }}</ref>		'''Anal squamous cell carcinoma''' is the most common type of [[anal cancer]].<ref name=pmid25741135>{{Cite journal \| last1 = Ghosn \| first1 = M. \| last2 = Kourie \| first2 = HR. \| last3 = Abdayem \| first3 = P. \| last4 = Antoun \| first4 = J. \| last5 = Nasr \| first5 = D. \| title = Anal cancer treatment: Current status and future perspectives. \| journal = World J Gastroenterol \| volume = 21 \| issue = 8 \| pages = 2294-2302 \| month = Feb \| year = 2015 \| doi = 10.3748/wjg.v21.i8.2294 \| PMID = 25741135 }}</ref>

Line 5:		Line 36:
	==General==		==General==
	*Most common form of anal cancer.<ref name=pmid25741135/>		*Most common form of anal cancer.<ref name=pmid25741135/>
			*Overall anal cancer uncommon.<ref name=pmid25741135/>
	*Strong association with [[HPV]].<ref name=pmid23616200>{{Cite journal \| last1 = Cornall \| first1 = AM. \| last2 = Roberts \| first2 = JM. \| last3 = Garland \| first3 = SM. \| last4 = Hillman \| first4 = RJ. \| last5 = Grulich \| first5 = AE. \| last6 = Tabrizi \| first6 = SN. \| title = Anal and perianal squamous carcinomas and high-grade intraepithelial lesions exclusively associated with "low-risk" HPV genotypes 6 and 11. \| journal = Int J Cancer \| volume = 133 \| issue = 9 \| pages = 2253-8 \| month = Nov \| year = 2013 \| doi = 10.1002/ijc.28228 \| PMID = 23616200 }}</ref>		*Strong association with [[HPV]].<ref name=pmid23616200>{{Cite journal \| last1 = Cornall \| first1 = AM. \| last2 = Roberts \| first2 = JM. \| last3 = Garland \| first3 = SM. \| last4 = Hillman \| first4 = RJ. \| last5 = Grulich \| first5 = AE. \| last6 = Tabrizi \| first6 = SN. \| title = Anal and perianal squamous carcinomas and high-grade intraepithelial lesions exclusively associated with "low-risk" HPV genotypes 6 and 11. \| journal = Int J Cancer \| volume = 133 \| issue = 9 \| pages = 2253-8 \| month = Nov \| year = 2013 \| doi = 10.1002/ijc.28228 \| PMID = 23616200 }}</ref>

Michael at 18:02, 19 March 2015

2015-03-19T18:02:14Z

← Older revision		Revision as of 18:02, 19 March 2015
Line 1:		Line 1:
	'''Anal squamous cell carcinoma''' is a type of [[anal cancer]].		'''Anal squamous cell carcinoma''' is the most common type of [[anal cancer]].<ref name=pmid25741135>{{Cite journal \| last1 = Ghosn \| first1 = M. \| last2 = Kourie \| first2 = HR. \| last3 = Abdayem \| first3 = P. \| last4 = Antoun \| first4 = J. \| last5 = Nasr \| first5 = D. \| title = Anal cancer treatment: Current status and future perspectives. \| journal = World J Gastroenterol \| volume = 21 \| issue = 8 \| pages = 2294-2302 \| month = Feb \| year = 2015 \| doi = 10.3748/wjg.v21.i8.2294 \| PMID = 25741135 }}</ref>

	It is also known as '''anal squamous carcinoma''' and '''squamous cell carcinoma of the anus'''.		It is also known as '''anal squamous carcinoma''' and '''squamous cell carcinoma of the anus'''.

	==General==		==General==
	*Most common form of anal cancer.		*Most common form of anal cancer.<ref name=pmid25741135/>
	*~~Associated~~ with [[HPV]] ~~infection~~.<ref name=pmid23616200>{{Cite journal \| last1 = Cornall \| first1 = AM. \| last2 = Roberts \| first2 = JM. \| last3 = Garland \| first3 = SM. \| last4 = Hillman \| first4 = RJ. \| last5 = Grulich \| first5 = AE. \| last6 = Tabrizi \| first6 = SN. \| title = Anal and perianal squamous carcinomas and high-grade intraepithelial lesions exclusively associated with "low-risk" HPV genotypes 6 and 11. \| journal = Int J Cancer \| volume = 133 \| issue = 9 \| pages = 2253-8 \| month = Nov \| year = 2013 \| doi = 10.1002/ijc.28228 \| PMID = 23616200 }}</ref>		*Strong association with [[HPV]].<ref name=pmid23616200>{{Cite journal \| last1 = Cornall \| first1 = AM. \| last2 = Roberts \| first2 = JM. \| last3 = Garland \| first3 = SM. \| last4 = Hillman \| first4 = RJ. \| last5 = Grulich \| first5 = AE. \| last6 = Tabrizi \| first6 = SN. \| title = Anal and perianal squamous carcinomas and high-grade intraepithelial lesions exclusively associated with "low-risk" HPV genotypes 6 and 11. \| journal = Int J Cancer \| volume = 133 \| issue = 9 \| pages = 2253-8 \| month = Nov \| year = 2013 \| doi = 10.1002/ijc.28228 \| PMID = 23616200 }}</ref>

	Risk factors:<ref name=pmid23806153>{{Cite journal \| last1 = Kutlubay \| first1 = Z. \| last2 = Engin \| first2 = B. \| last3 = Zara \| first3 = T. \| last4 = Tüzün \| first4 = Y. \| title = Anogenital malignancies and premalignancies: Facts and controversies. \| journal = Clin Dermatol \| volume = 31 \| issue = 4 \| pages = 362-73 \| month = \| year = \| doi = 10.1016/j.clindermatol.2013.01.003 \| PMID = 23806153 }}</ref>		Risk factors:<ref name=pmid23806153>{{Cite journal \| last1 = Kutlubay \| first1 = Z. \| last2 = Engin \| first2 = B. \| last3 = Zara \| first3 = T. \| last4 = Tüzün \| first4 = Y. \| title = Anogenital malignancies and premalignancies: Facts and controversies. \| journal = Clin Dermatol \| volume = 31 \| issue = 4 \| pages = 362-73 \| month = \| year = \| doi = 10.1016/j.clindermatol.2013.01.003 \| PMID = 23806153 }}</ref>

Michael: /* General */ +HPV link

2015-03-19T17:58:51Z

General: +HPV link

← Older revision		Revision as of 17:58, 19 March 2015
Line 5:		Line 5:
	==General==		==General==
	*Most common form of anal cancer.		*Most common form of anal cancer.
			*Associated with [[HPV]] infection.<ref name=pmid23616200>{{Cite journal \| last1 = Cornall \| first1 = AM. \| last2 = Roberts \| first2 = JM. \| last3 = Garland \| first3 = SM. \| last4 = Hillman \| first4 = RJ. \| last5 = Grulich \| first5 = AE. \| last6 = Tabrizi \| first6 = SN. \| title = Anal and perianal squamous carcinomas and high-grade intraepithelial lesions exclusively associated with "low-risk" HPV genotypes 6 and 11. \| journal = Int J Cancer \| volume = 133 \| issue = 9 \| pages = 2253-8 \| month = Nov \| year = 2013 \| doi = 10.1002/ijc.28228 \| PMID = 23616200 }}</ref>

	Risk factors:<ref name=pmid23806153>{{Cite journal \| last1 = Kutlubay \| first1 = Z. \| last2 = Engin \| first2 = B. \| last3 = Zara \| first3 = T. \| last4 = Tüzün \| first4 = Y. \| title = Anogenital malignancies and premalignancies: Facts and controversies. \| journal = Clin Dermatol \| volume = 31 \| issue = 4 \| pages = 362-73 \| month = \| year = \| doi = 10.1016/j.clindermatol.2013.01.003 \| PMID = 23806153 }}</ref>		Risk factors:<ref name=pmid23806153>{{Cite journal \| last1 = Kutlubay \| first1 = Z. \| last2 = Engin \| first2 = B. \| last3 = Zara \| first3 = T. \| last4 = Tüzün \| first4 = Y. \| title = Anogenital malignancies and premalignancies: Facts and controversies. \| journal = Clin Dermatol \| volume = 31 \| issue = 4 \| pages = 362-73 \| month = \| year = \| doi = 10.1016/j.clindermatol.2013.01.003 \| PMID = 23806153 }}</ref>
Line 10:		Line 11:
	*Immunosuppressed.		*Immunosuppressed.
	*[[HIV]] infection.		*[[HIV]] infection.

	==Microscopic==		==Microscopic==
	Features:		Features: