Alveolar soft part sarcoma - Revision history

Michael: /* Microscopic */ gr

2014-12-25T16:40:19Z

Microscopic: gr

← Older revision		Revision as of 16:40, 25 December 2014
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	==Microscopic==		==Microscopic==
	Features:<ref name=Ref_WMSP627>{{Ref WMSP\|627}}</ref>		Features:<ref name=Ref_WMSP627>{{Ref WMSP\|627}}</ref>
	*Arranged in ~~nest~~/separated by thin septa; vaguely resembles alveoli (at low power).		*Arranged in nests/separated by thin septa; vaguely resembles alveoli (at low power).
	*Large cells (~30-50 μm) with abundant eosinophilic cytoplasm.		*Large cells (~30-50 μm) with abundant eosinophilic cytoplasm.
	**May be focally cleared.		**May be focally cleared.

Michael at 16:39, 25 December 2014

2014-12-25T16:39:37Z

← Older revision		Revision as of 16:39, 25 December 2014
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	\| Width =		\| Width =
	\| Caption = ASPS. [[H&E stain]].		\| Caption = ASPS. [[H&E stain]].
	\| Micro = large cells (~30-50 μm) with abundant eosinophilic cytoplasm and an eccentric nucleus +/-nucleolus, arranged in ~~nest~~/separated by thin septa - vaguely resembles alveoli (at low power)		\| Micro = large cells (~30-50 μm) with abundant eosinophilic cytoplasm and an eccentric nucleus +/-nucleolus, arranged in nests/separated by thin septa - vaguely resembles alveoli (at low power)
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[paraganglioma]], [[clear cell renal cell carcinoma]], [[alveolar rhabdomyosarcoma]]		\| LMDDx = [[paraganglioma]], [[clear cell renal cell carcinoma]], [[alveolar rhabdomyosarcoma]]
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	\| ClinDDx =		\| ClinDDx =
	}}		}}
	'''Alveolar soft part sarcoma''', abbreviated '''ASPS''', is a rare malignant soft tissue lesion typically seen in younger individuals.		'''Alveolar soft part sarcoma''', abbreviated '''ASPS''', is a rare [[malignant]] soft tissue lesion typically seen in younger individuals.

	==General==		==General==

Michael at 18:49, 26 January 2014

2014-01-26T18:49:39Z

← Older revision		Revision as of 18:49, 26 January 2014
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	==General==		==General==
	*Adolescents/young adults.		*Adolescents/young adults.
	*Children -- classically location: base of [[tongue]] ~~and orbit~~.		*Children -- classically location: orbit and base of [[tongue]].<ref name=pmid21934227>{{Cite journal \| last1 = Anbarasi \| first1 = K. \| last2 = Sathasivasubramanian \| first2 = S. \| last3 = Kuruvilla \| first3 = S. \| title = Alveolar soft-part sarcoma of tongue. \| journal = Indian J Pathol Microbiol \| volume = 54 \| issue = 3 \| pages = 581-3 \| month = \| year = \| doi = 10.4103/0377-4929.85099 \| PMID = 21934227 }}</ref>
	*Typical indolent initially - ultimately a poor prognosis.<ref name=pmid17071801>{{Cite journal \| last1 = Folpe \| first1 = AL. \| last2 = Deyrup \| first2 = AT. \| title = Alveolar soft-part sarcoma: a review and update. \| journal = J Clin Pathol \| volume = 59 \| issue = 11 \| pages = 1127-32 \| month = Nov \| year = 2006 \| doi = 10.1136/jcp.2005.031120 \| PMID = 17071801 \|PMC = 1860509 \| URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860509/?tool=pubmed }}</ref>		*Typical indolent initially - ultimately a poor prognosis.<ref name=pmid17071801>{{Cite journal \| last1 = Folpe \| first1 = AL. \| last2 = Deyrup \| first2 = AT. \| title = Alveolar soft-part sarcoma: a review and update. \| journal = J Clin Pathol \| volume = 59 \| issue = 11 \| pages = 1127-32 \| month = Nov \| year = 2006 \| doi = 10.1136/jcp.2005.031120 \| PMID = 17071801 \|PMC = 1860509 \| URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860509/?tool=pubmed }}</ref>

Michael: /* Images */ tweak

2013-09-29T03:51:15Z

Images: tweak

← Older revision		Revision as of 03:51, 29 September 2013
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	===Images===		===Images===
	<gallery>		<gallery>
			Image:Alveolar soft part sarcoma - very low mag.jpg \| ASPS - very low mag. (WC/Nephron)
	Image:Alveolar_soft_part_sarcoma_-_low_mag.jpg \| ASPS - low mag. (WC/Nephron)		Image:Alveolar_soft_part_sarcoma_-_low_mag.jpg \| ASPS - low mag. (WC/Nephron)
	Image:Alveolar_soft_part_sarcoma_-_intermed_mag.jpg \| ASPS - intermed. mag. (WC/Nephron)		Image:Alveolar_soft_part_sarcoma_-_intermed_mag.jpg \| ASPS - intermed. mag. (WC/Nephron)
			Image:Alveolar soft part sarcoma - high mag.jpg \| ASPS - high mag. (WC/Nephron)
			Image:Alveolar soft part sarcoma - very high mag.jpg \| ASPS - very high mag. (WC/Nephron)
	Image:Alveolar_soft_part_sarcoma_-2-_very_high_mag.jpg \| ASPS - very high mag. (WC/Nephron)		Image:Alveolar_soft_part_sarcoma_-2-_very_high_mag.jpg \| ASPS - very high mag. (WC/Nephron)
	</gallery>		</gallery>
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	*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860509/figure/fig1/ ASPS - low mag. (nih.gov)].<ref name=pmid17071801/>		*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860509/figure/fig1/ ASPS - low mag. (nih.gov)].<ref name=pmid17071801/>
	*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860509/figure/fig5/ ASPS - high mag. (nih.gov)].<ref name=pmid17071801/>		*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860509/figure/fig5/ ASPS - high mag. (nih.gov)].<ref name=pmid17071801/>

	==Stains==		==Stains==
	*PAS +ve (cytoplasmic) - considered the most useful.<ref name=pmid17516754>{{Cite journal \| last1 = Zarrin-Khameh \| first1 = N. \| last2 = Kaye \| first2 = KS. \| title = Alveolar soft part sarcoma. \| journal = Arch Pathol Lab Med \| volume = 131 \| issue = 3 \| pages = 488-91 \| month = Mar \| year = 2007 \| doi = 10.1043/1543-2165(2007)131[488:ASPS]2.0.CO;2 \| PMID = 17516754 }}</ref>		*PAS +ve (cytoplasmic) - considered the most useful.<ref name=pmid17516754>{{Cite journal \| last1 = Zarrin-Khameh \| first1 = N. \| last2 = Kaye \| first2 = KS. \| title = Alveolar soft part sarcoma. \| journal = Arch Pathol Lab Med \| volume = 131 \| issue = 3 \| pages = 488-91 \| month = Mar \| year = 2007 \| doi = 10.1043/1543-2165(2007)131[488:ASPS]2.0.CO;2 \| PMID = 17516754 }}</ref>

Michael: tweak some more

2013-09-29T03:48:37Z

tweak some more

← Older revision		Revision as of 03:48, 29 September 2013
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	\| Micro = large cells (~30-50 μm) with abundant eosinophilic cytoplasm and an eccentric nucleus +/-nucleolus, arranged in nest/separated by thin septa - vaguely resembles alveoli (at low power)		\| Micro = large cells (~30-50 μm) with abundant eosinophilic cytoplasm and an eccentric nucleus +/-nucleolus, arranged in nest/separated by thin septa - vaguely resembles alveoli (at low power)
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[alveolar rhabdomyosarcoma]]		\| LMDDx = [[paraganglioma]], [[clear cell renal cell carcinoma]], [[alveolar rhabdomyosarcoma]]
	\| Stains = PAS +ve (cytoplasm)		\| Stains = PAS +ve (cytoplasm)
	\| IHC = TFE3 +ve (suggestive of translocation)		\| IHC = TFE3 +ve (suggestive of translocation)
	\| EM =		\| EM = intracytoplasmic crystal lattice with ~5 nm fibres spaced 10 nm apart
	\| Molecular = t(X;17)		\| Molecular = t(X;17)
	\| IF =		\| IF =
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	\| Assdx =		\| Assdx =
	\| Syndromes =		\| Syndromes =
	\| Clinicalhx =		\| Clinicalhx = usu. slow growing mass
	\| Signs =		\| Signs =
	\| Symptoms =		\| Symptoms =
	\| Prevalence =		\| Prevalence = rare
	\| Bloodwork =		\| Bloodwork =
	\| Rads =		\| Rads =
	\| Endoscopy =		\| Endoscopy =
	\| Prognosis = poor		\| Prognosis = ultimately poor
	\| Other =		\| Other =
	\| ClinDDx =		\| ClinDDx =
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	*Arranged in nest/separated by thin septa; vaguely resembles alveoli (at low power).		*Arranged in nest/separated by thin septa; vaguely resembles alveoli (at low power).
	*Large cells (~30-50 μm) with abundant eosinophilic cytoplasm.		*Large cells (~30-50 μm) with abundant eosinophilic cytoplasm.
			**May be focally cleared.
	*An eccentric nucleus.		*An eccentric nucleus.
	*+/-Nucleolus.		*+/-Nucleolus, prominent.
			*+/-Multi-nucleation (common).

	DDx:		DDx:
	*[[Rhabdomyosarcoma]], alveolar - usu. does not have sheets of rhabdoid cells.		*[[Paraganglioma]].
			*[[Clear cell renal cell carcinoma]] - areas with cytoplasmic clearing.
			*[[Rhabdomyosarcoma]], alveolar - usu. does not have sheets of rhabdoid cells, no cross striations.

	===Images===		===Images===
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	*HMB45 -ve.		*HMB45 -ve.
	*Melan‐A -ve.		*Melan‐A -ve.
			*Chromogranin A -ve.
			*Synaptophysin -ve.

	==Molecular==		==Molecular==

Michael: more

2013-09-29T03:40:36Z

← Older revision		Revision as of 03:40, 29 September 2013
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	www:		www:
	*[http://www.webpathology.com/image.asp?case=508&n=10 ASPS - PAS (webpathology.com)].		*[http://www.webpathology.com/image.asp?case=508&n=10 ASPS - PAS (webpathology.com)].
			*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860509/figure/fig1/ ASPS - low mag. (nih.gov)].<ref name=pmid17071801/>
			*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860509/figure/fig5/ ASPS - high mag. (nih.gov)].<ref name=pmid17071801/>
	==Stains==		==Stains==
	*PAS +ve (cytoplasmic) - considered the most useful.<ref name=pmid17516754>{{Cite journal \| last1 = Zarrin-Khameh \| first1 = N. \| last2 = Kaye \| first2 = KS. \| title = Alveolar soft part sarcoma. \| journal = Arch Pathol Lab Med \| volume = 131 \| issue = 3 \| pages = 488-91 \| month = Mar \| year = 2007 \| doi = 10.1043/1543-2165(2007)131[488:ASPS]2.0.CO;2 \| PMID = 17516754 }}</ref>		*PAS +ve (cytoplasmic) - considered the most useful.<ref name=pmid17516754>{{Cite journal \| last1 = Zarrin-Khameh \| first1 = N. \| last2 = Kaye \| first2 = KS. \| title = Alveolar soft part sarcoma. \| journal = Arch Pathol Lab Med \| volume = 131 \| issue = 3 \| pages = 488-91 \| month = Mar \| year = 2007 \| doi = 10.1043/1543-2165(2007)131[488:ASPS]2.0.CO;2 \| PMID = 17516754 }}</ref>

Michael at 03:37, 29 September 2013

2013-09-29T03:37:41Z

← Older revision		Revision as of 03:37, 29 September 2013
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	==IHC==		==IHC==
	*TFE3 +ve -- suggestive of characteristic translocation.		*TFE3 +ve -- suggestive of characteristic translocation.
	*Desmin ~ 50% of cases.		*Desmin ~ 50% of cases.<ref name=pmid17071801/>

	Others:		Others:<ref name=pmid17071801/>
	*EMA -ve.		*EMA -ve.
	*Cytokeratins -ve.		*Cytokeratins -ve.

Michael: /* IHC */

2013-09-29T03:37:08Z

IHC

← Older revision		Revision as of 03:37, 29 September 2013
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	==IHC==		==IHC==
	*TFE3 +ve -- suggestive of characteristic translocation.		*TFE3 +ve -- suggestive of characteristic translocation.
			*Desmin ~ 50% of cases.

			Others:
			*EMA -ve.
			*Cytokeratins -ve.
			*HMB45 -ve.
			*Melan‐A -ve.

	==Molecular==		==Molecular==

Michael: split-out with infobox

2013-09-29T03:30:27Z

split-out with infobox

← Older revision		Revision as of 03:30, 29 September 2013
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	~~#redirect~~ [[~~Soft_tissue_lesions#Alveolar_soft_part_sarcoma~~]]		{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Alveolar_soft_part_sarcoma_-2-_very_high_mag.jpg
			\| Width =
			\| Caption = ASPS. [[H&E stain]].
			\| Micro = large cells (~30-50 μm) with abundant eosinophilic cytoplasm and an eccentric nucleus +/-nucleolus, arranged in nest/separated by thin septa - vaguely resembles alveoli (at low power)
			\| Subtypes =
			\| LMDDx = [[alveolar rhabdomyosarcoma]]
			\| Stains = PAS +ve (cytoplasm)
			\| IHC = TFE3 +ve (suggestive of translocation)
			\| EM =
			\| Molecular = t(X;17)
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[soft tissue lesions\|soft tissue]] - usu. [[head and neck pathology\|head and neck]]
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence =
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = poor
			\| Other =
			\| ClinDDx =
			}}
			'''Alveolar soft part sarcoma''', abbreviated '''ASPS''', is a rare malignant soft tissue lesion typically seen in younger individuals.

			==General==
			*Adolescents/young adults.
			*Children -- classically location: base of [[tongue]] and orbit.
			*Typical indolent initially - ultimately a poor prognosis.<ref name=pmid17071801>{{Cite journal \| last1 = Folpe \| first1 = AL. \| last2 = Deyrup \| first2 = AT. \| title = Alveolar soft-part sarcoma: a review and update. \| journal = J Clin Pathol \| volume = 59 \| issue = 11 \| pages = 1127-32 \| month = Nov \| year = 2006 \| doi = 10.1136/jcp.2005.031120 \| PMID = 17071801 \|PMC = 1860509 \| URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860509/?tool=pubmed }}</ref>

			==Microscopic==
			Features:<ref name=Ref_WMSP627>{{Ref WMSP\|627}}</ref>
			*Arranged in nest/separated by thin septa; vaguely resembles alveoli (at low power).
			*Large cells (~30-50 μm) with abundant eosinophilic cytoplasm.
			*An eccentric nucleus.
			*+/-Nucleolus.

			DDx:
			*[[Rhabdomyosarcoma]], alveolar - usu. does not have sheets of rhabdoid cells.

			===Images===
			<gallery>
			Image:Alveolar_soft_part_sarcoma_-_low_mag.jpg \| ASPS - low mag. (WC/Nephron)
			Image:Alveolar_soft_part_sarcoma_-_intermed_mag.jpg \| ASPS - intermed. mag. (WC/Nephron)
			Image:Alveolar_soft_part_sarcoma_-2-_very_high_mag.jpg \| ASPS - very high mag. (WC/Nephron)
			</gallery>
			www:
			*[http://www.webpathology.com/image.asp?case=508&n=10 ASPS - PAS (webpathology.com)].

			==Stains==
			*PAS +ve (cytoplasmic) - considered the most useful.<ref name=pmid17516754>{{Cite journal \| last1 = Zarrin-Khameh \| first1 = N. \| last2 = Kaye \| first2 = KS. \| title = Alveolar soft part sarcoma. \| journal = Arch Pathol Lab Med \| volume = 131 \| issue = 3 \| pages = 488-91 \| month = Mar \| year = 2007 \| doi = 10.1043/1543-2165(2007)131[488:ASPS]2.0.CO;2 \| PMID = 17516754 }}</ref>
			*PASD +ve (cytoplasmic).

			==IHC==
			*TFE3 +ve -- suggestive of characteristic translocation.

			==Molecular==
			*t(X;17)(p11.2;q25).<ref>{{OMIM\|606243}}</ref>

			Note:
			*Same translocation may be seen in ''[[renal tumour with Xp11.2 translocation]]''.

			==EM==
			*Distinctive membrane-bound intracytoplasmic crystal lattice with ~5 nm fibres spaced 10 nm apart.<ref name=pmid17071801/>

			Image:
			*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860509/figure/fig8/ Distinctive crystal lattice in ASPS (nlm.nih.gov)].<ref name=pmid17071801/>

			==See also==
			*[[Soft tissue lesions]].
			*[[Head and neck pathology]].

			==References==
			{{Reflist\|2}}

			[[Category:Soft tissue lesions]]
	[[Category:Diagnosis]]		[[Category:Diagnosis]]

Michael: +cat.

2011-10-20T05:06:57Z

+cat.

← Older revision		Revision as of 05:06, 20 October 2011
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	#redirect [[Soft_tissue_lesions#Alveolar_soft_part_sarcoma]]		#redirect [[Soft_tissue_lesions#Alveolar_soft_part_sarcoma]]

			[[Category:Diagnosis]]