Alpha-1 antitrypsin deficiency - Revision history

Mitchell: /* Images */ added a case

2017-01-09T21:11:36Z

Images: added a case

← Older revision		Revision as of 21:11, 9 January 2017
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	Image:Alpha-1 antitrypsin deficiency.PAS Diastase.jpg \| Alpha-1 AT deficiency - PASD. (WC/JMGardner)		Image:Alpha-1 antitrypsin deficiency.PAS Diastase.jpg \| Alpha-1 AT deficiency - PASD. (WC/JMGardner)
	</gallery>		</gallery>
	{\|		[[File:4 37975578915035 sl 1.png\|Alpha 1 anti-trypsin deficiency in 29 year old woman.]]
	[[File:1 A1AT 1 680x512px.tif\| Alpha 1 Antitrypsin deficiency with cirrhosis]]		[[File:4 37975578915035 sl 2.png\|Alpha 1 anti-trypsin deficiency in 29 year old woman.]]
	[[File:2 A1AT 1 680x512px.tif\| Alpha 1 Antitrypsin deficiency with cirrhosis]]		[[File:4 37975578915035 sl 3.png\|Alpha 1 anti-trypsin deficiency in 29 year old woman.]]
	<br>		[[File:4 37975578915035 sl 4.png\|Alpha 1 anti-trypsin deficiency in 29 year old woman.]]<br>
	[[File:3 A1AT 1 680x512px.tif\| Alpha 1 Antitrypsin deficiency with cirrhosis]]		Alpha 1 anti-trypsin deficiency in 29 year old woman. A. At low power, there is focal steatosis and mild inflammation of portal triads. B. Foci of steatosis show rare tufts of ballooning degeneration (arrow). C. A few triads had infiltrates of macrophages and lymphocytes, none with definite interface hepatitis; note the space between the hepatocytes and the inflammatory cells. D. PAS-D showed splotches of hepatocytes with PAS-D granules. The patient was already known to have A1AT deficiency.
	[[File:4 A1AT 1 680x512px.tif\| Alpha 1 Antitrypsin deficiency with cirrhosis]]
	<br>
	[[File:5 A1AT 1 680x512px.tif\| Alpha 1 Antitrypsin deficiency with cirrhosis]]		A. [[File:1 A1AT 1 680x512px.tif\| Alpha 1 Antitrypsin deficiency with cirrhosis]]<br>
	[[File:6 A1AT 1 680x512px.tif\| Alpha 1 Antitrypsin deficiency with cirrhosis]]		B. [[File:2 A1AT 1 680x512px.tif\| Alpha 1 Antitrypsin deficiency with cirrhosis]]<br>
	\|}		C. [[File:3 A1AT 1 680x512px.tif\| Alpha 1 Antitrypsin deficiency with cirrhosis]]<br>
	Alpha 1 Antitrypsin deficiency with cirrhosis. Dark inflamed bands bound hepatocyte nodules ~~(Row 1 Left 40X)~~. Steatosis afflicts some hepatocyte areas, within inflamed band lie proliferated bile ductules ~~(Row 1 Right 100X)~~. Reticulin shows regenerative (more than 2 nuclei per cord) nodules (black lines without definite directionality) amid bands ~~(Row 2 Left 100X)~~. Trichrome shows scar ~~(Row 2 Right 100X)~~. Hepatocytes show steatosis, foamy degeneration, and intranuclear inclusions ~~(Row 3 Left 400X)~~. PAS-D shows A1AT cytoplasmic granules; in non-A1AT cirrhosis, these granules would neither be in so many hepatocytes nor, in general, as large ~~(Row 3 Right 400X)~~.		D. [[File:4 A1AT 1 680x512px.tif\| Alpha 1 Antitrypsin deficiency with cirrhosis]]<br>
	{\|		E. [[File:5 A1AT 1 680x512px.tif\| Alpha 1 Antitrypsin deficiency with cirrhosis]]<br>
			F. [[File:6 A1AT 1 680x512px.tif\| Alpha 1 Antitrypsin deficiency with cirrhosis]]<br>

			Alpha 1 Antitrypsin deficiency with cirrhosis. A. Dark inflamed bands bound hepatocyte nodules. B. Steatosis afflicts some hepatocyte areas, within inflamed band lie proliferated bile ductules. C. Reticulin shows regenerative (more than 2 nuclei per cord) nodules (black lines without definite directionality) amid bands. D. Trichrome shows scar. E. Hepatocytes show steatosis, foamy degeneration, and intranuclear inclusions. F. PAS-D shows A1AT cytoplasmic granules; in non-A1AT cirrhosis, these granules would neither be in so many hepatocytes nor, in general, as large.

	[[File:1 A1AT 2 680x512px.tif\| Alpha 1 anti-trypsin (A1AT) granules in cirrhosis, not due to A1AT deficiency; A1AT level was normal.]]		[[File:1 A1AT 2 680x512px.tif\| Alpha 1 anti-trypsin (A1AT) granules in cirrhosis, not due to A1AT deficiency; A1AT level was normal.]]
	[[File:2 A1AT 2 680x512px.tif\| Alpha 1 anti-trypsin (A1AT) granules in cirrhosis, not due to A1AT deficiency; A1AT level was normal.]]		[[File:2 A1AT 2 680x512px.tif\| Alpha 1 anti-trypsin (A1AT) granules in cirrhosis, not due to A1AT deficiency; A1AT level was normal.]]
	~~<br>~~
	[[File:3 A1AT 2 680x512px.tif\| Alpha 1 anti-trypsin (A1AT) granules in cirrhosis, not due to A1AT deficiency; A1AT level was normal.]]		[[File:3 A1AT 2 680x512px.tif\| Alpha 1 anti-trypsin (A1AT) granules in cirrhosis, not due to A1AT deficiency; A1AT level was normal.]]
	[[File:4 A1AT 2 680x512px.tif\| Alpha 1 anti-trypsin (A1AT) granules in cirrhosis, not due to A1AT deficiency; A1AT level was normal.]]		[[File:4 A1AT 2 680x512px.tif\| Alpha 1 anti-trypsin (A1AT) granules in cirrhosis, not due to A1AT deficiency; A1AT level was normal.]]
	~~<br>~~
	[[File:5 A1AT 2 680x512px.tif\| Alpha 1 anti-trypsin (A1AT) granules in cirrhosis, not due to A1AT deficiency; A1AT level was normal.]]		[[File:5 A1AT 2 680x512px.tif\| Alpha 1 anti-trypsin (A1AT) granules in cirrhosis, not due to A1AT deficiency; A1AT level was normal.]]
	[[File:6 A1AT 2 680x512px.tif\| Alpha 1 anti-trypsin (A1AT) granules in cirrhosis, not due to A1AT deficiency; A1AT level was normal.]]		[[File:6 A1AT 2 680x512px.tif\| Alpha 1 anti-trypsin (A1AT) granules in cirrhosis, not due to A1AT deficiency; A1AT level was normal.]]<br>
	\|}
	Alpha 1 anti-trypsin (A1AT) granules in cirrhosis, not due to A1AT deficiency; A1AT level was normal. A. Low power shows an inflamed foci, bands, and hepatocyte regions ~~[2x]~~. B. Trichrome confirms blue fibrosis about hepatocyte isles ~~[4X]~~. C. Proliferated bile ductules (black arrows) border hepatocytes with glycogenated nuclei (green arrows), consistent with the history of diabetes ~~[200X]~~. D. Reticulin shows two-cell thick regenerated cords (green arrows) and circles for rosettes (black arrows) ~~[200X]~~. E. PAS with diastase stain shows occasional small red granules (arrows) and red dust in cytoplasm of hepatocytes near edge of regenerative nodule ~~[400X]~~. E. A1AT immunostain shows occasional small brown granules (arrows) in cytoplasm of hepatocytes near edge of regenerative nodule ~~[400X]~~.		Alpha 1 anti-trypsin (A1AT) granules in cirrhosis, not due to A1AT deficiency; A1AT level was normal. A. Low power shows an inflamed foci, bands, and hepatocyte regions. B. Trichrome confirms blue fibrosis about hepatocyte isles. C. Proliferated bile ductules (black arrows) border hepatocytes with glycogenated nuclei (green arrows), consistent with the history of diabetes. D. Reticulin shows two-cell thick regenerated cords (green arrows) and circles for rosettes (black arrows). E. PAS with diastase stain shows occasional small red granules (arrows) and red dust in cytoplasm of hepatocytes near edge of regenerative nodule. E. A1AT immunostain shows occasional small brown granules (arrows) in cytoplasm of hepatocytes near edge of regenerative nodule.

	www:		www:

Mitchell: /* Images */ Added a case with non-specific staining

2016-10-20T16:33:05Z

Images: Added a case with non-specific staining

← Older revision		Revision as of 16:33, 20 October 2016
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	\|}		\|}
	Alpha 1 Antitrypsin deficiency with cirrhosis. Dark inflamed bands bound hepatocyte nodules (Row 1 Left 40X). Steatosis afflicts some hepatocyte areas, within inflamed band lie proliferated bile ductules (Row 1 Right 100X). Reticulin shows regenerative (more than 2 nuclei per cord) nodules (black lines without definite directionality) amid bands (Row 2 Left 100X). Trichrome shows scar (Row 2 Right 100X). Hepatocytes show steatosis, foamy degeneration, and intranuclear inclusions (Row 3 Left 400X). PAS-D shows A1AT cytoplasmic granules; in non-A1AT cirrhosis, these granules would neither be in so many hepatocytes nor, in general, as large (Row 3 Right 400X).		Alpha 1 Antitrypsin deficiency with cirrhosis. Dark inflamed bands bound hepatocyte nodules (Row 1 Left 40X). Steatosis afflicts some hepatocyte areas, within inflamed band lie proliferated bile ductules (Row 1 Right 100X). Reticulin shows regenerative (more than 2 nuclei per cord) nodules (black lines without definite directionality) amid bands (Row 2 Left 100X). Trichrome shows scar (Row 2 Right 100X). Hepatocytes show steatosis, foamy degeneration, and intranuclear inclusions (Row 3 Left 400X). PAS-D shows A1AT cytoplasmic granules; in non-A1AT cirrhosis, these granules would neither be in so many hepatocytes nor, in general, as large (Row 3 Right 400X).
			{\|
			[[File:1 A1AT 2 680x512px.tif\| Alpha 1 anti-trypsin (A1AT) granules in cirrhosis, not due to A1AT deficiency; A1AT level was normal.]]
			[[File:2 A1AT 2 680x512px.tif\| Alpha 1 anti-trypsin (A1AT) granules in cirrhosis, not due to A1AT deficiency; A1AT level was normal.]]
			<br>
			[[File:3 A1AT 2 680x512px.tif\| Alpha 1 anti-trypsin (A1AT) granules in cirrhosis, not due to A1AT deficiency; A1AT level was normal.]]
			[[File:4 A1AT 2 680x512px.tif\| Alpha 1 anti-trypsin (A1AT) granules in cirrhosis, not due to A1AT deficiency; A1AT level was normal.]]
			<br>
			[[File:5 A1AT 2 680x512px.tif\| Alpha 1 anti-trypsin (A1AT) granules in cirrhosis, not due to A1AT deficiency; A1AT level was normal.]]
			[[File:6 A1AT 2 680x512px.tif\| Alpha 1 anti-trypsin (A1AT) granules in cirrhosis, not due to A1AT deficiency; A1AT level was normal.]]
			\|}
			Alpha 1 anti-trypsin (A1AT) granules in cirrhosis, not due to A1AT deficiency; A1AT level was normal. A. Low power shows an inflamed foci, bands, and hepatocyte regions [2x]. B. Trichrome confirms blue fibrosis about hepatocyte isles [4X]. C. Proliferated bile ductules (black arrows) border hepatocytes with glycogenated nuclei (green arrows), consistent with the history of diabetes [200X]. D. Reticulin shows two-cell thick regenerated cords (green arrows) and circles for rosettes (black arrows) [200X]. E. PAS with diastase stain shows occasional small red granules (arrows) and red dust in cytoplasm of hepatocytes near edge of regenerative nodule [400X]. E. A1AT immunostain shows occasional small brown granules (arrows) in cytoplasm of hepatocytes near edge of regenerative nodule [400X].

	www:		www:

Mitchell: /* Images */ added a case

2016-09-06T20:26:57Z

Images: added a case

← Older revision		Revision as of 20:26, 6 September 2016
Line 61:		Line 61:
	Image:Alpha-1 antitrypsin deficiency.PAS Diastase.jpg \| Alpha-1 AT deficiency - PASD. (WC/JMGardner)		Image:Alpha-1 antitrypsin deficiency.PAS Diastase.jpg \| Alpha-1 AT deficiency - PASD. (WC/JMGardner)
	</gallery>		</gallery>
			{\|
			[[File:1 A1AT 1 680x512px.tif\| Alpha 1 Antitrypsin deficiency with cirrhosis]]
			[[File:2 A1AT 1 680x512px.tif\| Alpha 1 Antitrypsin deficiency with cirrhosis]]
			<br>
			[[File:3 A1AT 1 680x512px.tif\| Alpha 1 Antitrypsin deficiency with cirrhosis]]
			[[File:4 A1AT 1 680x512px.tif\| Alpha 1 Antitrypsin deficiency with cirrhosis]]
			<br>
			[[File:5 A1AT 1 680x512px.tif\| Alpha 1 Antitrypsin deficiency with cirrhosis]]
			[[File:6 A1AT 1 680x512px.tif\| Alpha 1 Antitrypsin deficiency with cirrhosis]]
			\|}
			Alpha 1 Antitrypsin deficiency with cirrhosis. Dark inflamed bands bound hepatocyte nodules (Row 1 Left 40X). Steatosis afflicts some hepatocyte areas, within inflamed band lie proliferated bile ductules (Row 1 Right 100X). Reticulin shows regenerative (more than 2 nuclei per cord) nodules (black lines without definite directionality) amid bands (Row 2 Left 100X). Trichrome shows scar (Row 2 Right 100X). Hepatocytes show steatosis, foamy degeneration, and intranuclear inclusions (Row 3 Left 400X). PAS-D shows A1AT cytoplasmic granules; in non-A1AT cirrhosis, these granules would neither be in so many hepatocytes nor, in general, as large (Row 3 Right 400X).

	www:		www:
	*[http://moon.ouhsc.edu/kfung/jty1/opaq/pathquiz/l1k001-pq01.htm Alpha-1 AT (ouhsc.edu)].		*[http://moon.ouhsc.edu/kfung/jty1/opaq/pathquiz/l1k001-pq01.htm Alpha-1 AT (ouhsc.edu)].

Michael: /* Microscopic */

2014-10-26T02:59:36Z

Microscopic

← Older revision		Revision as of 02:59, 26 October 2014
Line 55:		Line 55:

	Note:		Note:
	*The pink globules may be seen in the context of cirrhosis; cases should be ~~confirmation~~ with IHC.		*The pink globules may be seen in the context of cirrhosis; cases should be confirmed with IHC.

	===Images===		===Images===

Michael: +infobox

2014-10-26T02:59:15Z

+infobox

← Older revision		Revision as of 02:59, 26 October 2014
Line 1:		Line 1:
			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Alpha-1 antitrypsin deficiency.PAS Diastase.jpg
			\| Width =
			\| Caption = Alpha-1 AT deficiency. [[PASD stain]].
			\| Synonyms = alpha1-antiprotease inhibitor deficiency
			\| Micro = +/-pink globules in zone 1 (periportal), +/-fibrosis or [[cirrhosis]]
			\| Subtypes =
			\| LMDDx =
			\| Stains = PASD +ve (pink globules in zone 1) - not seen in children
			\| IHC = A1-AT +ve globules
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[liver]] - see ''[[medical liver disease]]'', [[lung]] - see ''[[emphysema]]''
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence = uncommon (1 in 2000-5000)
			\| Bloodwork =
			\| Rads = emphysematous changes (chest x-ray)
			\| Endoscopy =
			\| Prognosis =
			\| Other =
			\| ClinDDx =
			\| Tx =
			}}
	'''Alpha-1 antitrypsin deficiency''', abbreviated '''A1-AT''', is a relatively common genetic condition that causes lung and liver pathology.		'''Alpha-1 antitrypsin deficiency''', abbreviated '''A1-AT''', is a relatively common genetic condition that causes lung and liver pathology.

Michael: split -out

2014-10-26T02:36:36Z

split -out

← Older revision		Revision as of 02:36, 26 October 2014
Line 1:		Line 1:
	~~#redirect~~ [[~~Medical_liver_disease#~~Alpha-1_antitrypsin_deficiency]]		'''Alpha-1 antitrypsin deficiency''', abbreviated '''A1-AT''', is a relatively common genetic condition that causes lung and liver pathology.

			It is also known as '''alpha1-antiprotease inhibitor deficiency'''.

			This article deals with the [[medical liver disease\|liver pathology]]. The lung pathology is ''panlobular emphysema'' and covered in the ''[[emphysema]]'' article.

			==General==
			Etiology:
			*Genetic defect.
			**Prevalence 1 in 2000-5000.<ref name=pmid21960536>{{Cite journal \| last1 = Stoller \| first1 = JK. \| last2 = Aboussouan \| first2 = LS. \| title = A Review of Alpha-1 Antitrypsin Deficiency. \| journal = Am J Respir Crit Care Med \| volume = \| issue = \| pages = \| month = Sep \| year = 2011 \| doi = 10.1164/rccm.201108-1428CI \| PMID = 21960536 }}
			</ref>

			Causes:
			*Lung and liver injury.
			**Lung -> panlobular [[emphysema]].

			==Microscopic==
			Features:
			*Pink globules in zone 1 (periportal).
			**Globules ''not'' seen in children.
			**May ''not'' be present in late stage (cirrhotic).
			**Best seen on [[PASD stain]].
			**Can be seen on H&E -- if one looks carefully.

			Note:
			*The pink globules may be seen in the context of cirrhosis; cases should be confirmation with IHC.

			===Images===
			<gallery>
			Image:Alpha-1 antitrypsin deficiency.PAS Diastase.jpg \| Alpha-1 AT deficiency - PASD. (WC/JMGardner)
			</gallery>
			www:
			*[http://moon.ouhsc.edu/kfung/jty1/opaq/pathquiz/l1k001-pq01.htm Alpha-1 AT (ouhsc.edu)].
			*[http://www.pathpedia.com/Education/eAtlas/Histopathology/Liver_and_bile_ducts/Alpha-1_antitrypsin_deficiency.aspx Alpha-1 AT (pathpedia.com)].

			==Stains==
			*PAS +ve.<ref name=pmid6189389>{{Cite journal \| last1 = Qizilbash \| first1 = A. \| last2 = Young-Pong \| first2 = O. \| title = Alpha 1 antitrypsin liver disease differential diagnosis of PAS-positive, diastase-resistant globules in liver cells. \| journal = Am J Clin Pathol \| volume = 79 \| issue = 6 \| pages = 697-702 \| month = Jun \| year = 1983 \| doi = \| PMID = 6189389 }}</ref>
			*PASD +ve.<ref name=pmid6189389/>

			==IHC==
			*A1-AT +ve globules.<Ref name=pmid3512609>{{Cite journal \| last1 = Theaker \| first1 = JM. \| last2 = Fleming \| first2 = KA. \| title = Alpha-1-antitrypsin and the liver: a routine immunohistological screen. \| journal = J Clin Pathol \| volume = 39 \| issue = 1 \| pages = 58-62 \| month = Jan \| year = 1986 \| doi = \| PMID = 3512609 }}</ref>

			==See also==
			*[[Medical liver disease]].

			==References==
			{{Reflist\|2}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Medical liver disease]]
			[[Category:Pulmonary pathology]]

Michael: redirect +cat.

2011-10-26T04:35:49Z

redirect +cat.

New page

#redirect [[Medical_liver_disease#Alpha-1_antitrypsin_deficiency]]

[[Category:Diagnosis]]

← Older revision		Revision as of 21:11, 9 January 2017
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	Image:Alpha-1 antitrypsin deficiency.PAS Diastase.jpg \| Alpha-1 AT deficiency - PASD. (WC/JMGardner)		Image:Alpha-1 antitrypsin deficiency.PAS Diastase.jpg \| Alpha-1 AT deficiency - PASD. (WC/JMGardner)
	</gallery>		</gallery>
	{\|		[[File:4 37975578915035 sl 1.png\|Alpha 1 anti-trypsin deficiency in 29 year old woman.]]
	[[File:1 A1AT 1 680x512px.tif\| Alpha 1 Antitrypsin deficiency with cirrhosis]]		[[File:4 37975578915035 sl 2.png\|Alpha 1 anti-trypsin deficiency in 29 year old woman.]]
	[[File:2 A1AT 1 680x512px.tif\| Alpha 1 Antitrypsin deficiency with cirrhosis]]		[[File:4 37975578915035 sl 3.png\|Alpha 1 anti-trypsin deficiency in 29 year old woman.]]
	<br>		[[File:4 37975578915035 sl 4.png\|Alpha 1 anti-trypsin deficiency in 29 year old woman.]]<br>
	[[File:3 A1AT 1 680x512px.tif\| Alpha 1 Antitrypsin deficiency with cirrhosis]]		Alpha 1 anti-trypsin deficiency in 29 year old woman. A. At low power, there is focal steatosis and mild inflammation of portal triads. B. Foci of steatosis show rare tufts of ballooning degeneration (arrow). C. A few triads had infiltrates of macrophages and lymphocytes, none with definite interface hepatitis; note the space between the hepatocytes and the inflammatory cells. D. PAS-D showed splotches of hepatocytes with PAS-D granules. The patient was already known to have A1AT deficiency.
	[[File:4 A1AT 1 680x512px.tif\| Alpha 1 Antitrypsin deficiency with cirrhosis]]
	<br>
	[[File:5 A1AT 1 680x512px.tif\| Alpha 1 Antitrypsin deficiency with cirrhosis]]		A. [[File:1 A1AT 1 680x512px.tif\| Alpha 1 Antitrypsin deficiency with cirrhosis]]<br>
	[[File:6 A1AT 1 680x512px.tif\| Alpha 1 Antitrypsin deficiency with cirrhosis]]		B. [[File:2 A1AT 1 680x512px.tif\| Alpha 1 Antitrypsin deficiency with cirrhosis]]<br>
	\|}		C. [[File:3 A1AT 1 680x512px.tif\| Alpha 1 Antitrypsin deficiency with cirrhosis]]<br>
	Alpha 1 Antitrypsin deficiency with cirrhosis. Dark inflamed bands bound hepatocyte nodules ~~(Row 1 Left 40X)~~. Steatosis afflicts some hepatocyte areas, within inflamed band lie proliferated bile ductules ~~(Row 1 Right 100X)~~. Reticulin shows regenerative (more than 2 nuclei per cord) nodules (black lines without definite directionality) amid bands ~~(Row 2 Left 100X)~~. Trichrome shows scar ~~(Row 2 Right 100X)~~. Hepatocytes show steatosis, foamy degeneration, and intranuclear inclusions ~~(Row 3 Left 400X)~~. PAS-D shows A1AT cytoplasmic granules; in non-A1AT cirrhosis, these granules would neither be in so many hepatocytes nor, in general, as large ~~(Row 3 Right 400X)~~.		D. [[File:4 A1AT 1 680x512px.tif\| Alpha 1 Antitrypsin deficiency with cirrhosis]]<br>
	{\|		E. [[File:5 A1AT 1 680x512px.tif\| Alpha 1 Antitrypsin deficiency with cirrhosis]]<br>
			F. [[File:6 A1AT 1 680x512px.tif\| Alpha 1 Antitrypsin deficiency with cirrhosis]]<br>

			Alpha 1 Antitrypsin deficiency with cirrhosis. A. Dark inflamed bands bound hepatocyte nodules. B. Steatosis afflicts some hepatocyte areas, within inflamed band lie proliferated bile ductules. C. Reticulin shows regenerative (more than 2 nuclei per cord) nodules (black lines without definite directionality) amid bands. D. Trichrome shows scar. E. Hepatocytes show steatosis, foamy degeneration, and intranuclear inclusions. F. PAS-D shows A1AT cytoplasmic granules; in non-A1AT cirrhosis, these granules would neither be in so many hepatocytes nor, in general, as large.

	[[File:1 A1AT 2 680x512px.tif\| Alpha 1 anti-trypsin (A1AT) granules in cirrhosis, not due to A1AT deficiency; A1AT level was normal.]]		[[File:1 A1AT 2 680x512px.tif\| Alpha 1 anti-trypsin (A1AT) granules in cirrhosis, not due to A1AT deficiency; A1AT level was normal.]]
	[[File:2 A1AT 2 680x512px.tif\| Alpha 1 anti-trypsin (A1AT) granules in cirrhosis, not due to A1AT deficiency; A1AT level was normal.]]		[[File:2 A1AT 2 680x512px.tif\| Alpha 1 anti-trypsin (A1AT) granules in cirrhosis, not due to A1AT deficiency; A1AT level was normal.]]
	~~<br>~~
	[[File:3 A1AT 2 680x512px.tif\| Alpha 1 anti-trypsin (A1AT) granules in cirrhosis, not due to A1AT deficiency; A1AT level was normal.]]		[[File:3 A1AT 2 680x512px.tif\| Alpha 1 anti-trypsin (A1AT) granules in cirrhosis, not due to A1AT deficiency; A1AT level was normal.]]
	[[File:4 A1AT 2 680x512px.tif\| Alpha 1 anti-trypsin (A1AT) granules in cirrhosis, not due to A1AT deficiency; A1AT level was normal.]]		[[File:4 A1AT 2 680x512px.tif\| Alpha 1 anti-trypsin (A1AT) granules in cirrhosis, not due to A1AT deficiency; A1AT level was normal.]]
	~~<br>~~
	[[File:5 A1AT 2 680x512px.tif\| Alpha 1 anti-trypsin (A1AT) granules in cirrhosis, not due to A1AT deficiency; A1AT level was normal.]]		[[File:5 A1AT 2 680x512px.tif\| Alpha 1 anti-trypsin (A1AT) granules in cirrhosis, not due to A1AT deficiency; A1AT level was normal.]]
	[[File:6 A1AT 2 680x512px.tif\| Alpha 1 anti-trypsin (A1AT) granules in cirrhosis, not due to A1AT deficiency; A1AT level was normal.]]		[[File:6 A1AT 2 680x512px.tif\| Alpha 1 anti-trypsin (A1AT) granules in cirrhosis, not due to A1AT deficiency; A1AT level was normal.]]<br>
	\|}
	Alpha 1 anti-trypsin (A1AT) granules in cirrhosis, not due to A1AT deficiency; A1AT level was normal. A. Low power shows an inflamed foci, bands, and hepatocyte regions ~~[2x]~~. B. Trichrome confirms blue fibrosis about hepatocyte isles ~~[4X]~~. C. Proliferated bile ductules (black arrows) border hepatocytes with glycogenated nuclei (green arrows), consistent with the history of diabetes ~~[200X]~~. D. Reticulin shows two-cell thick regenerated cords (green arrows) and circles for rosettes (black arrows) ~~[200X]~~. E. PAS with diastase stain shows occasional small red granules (arrows) and red dust in cytoplasm of hepatocytes near edge of regenerative nodule ~~[400X]~~. E. A1AT immunostain shows occasional small brown granules (arrows) in cytoplasm of hepatocytes near edge of regenerative nodule ~~[400X]~~.		Alpha 1 anti-trypsin (A1AT) granules in cirrhosis, not due to A1AT deficiency; A1AT level was normal. A. Low power shows an inflamed foci, bands, and hepatocyte regions. B. Trichrome confirms blue fibrosis about hepatocyte isles. C. Proliferated bile ductules (black arrows) border hepatocytes with glycogenated nuclei (green arrows), consistent with the history of diabetes. D. Reticulin shows two-cell thick regenerated cords (green arrows) and circles for rosettes (black arrows). E. PAS with diastase stain shows occasional small red granules (arrows) and red dust in cytoplasm of hepatocytes near edge of regenerative nodule. E. A1AT immunostain shows occasional small brown granules (arrows) in cytoplasm of hepatocytes near edge of regenerative nodule.

	www:		www: