Adrenal cortical adenoma - Revision history

Michael: /* Microscopic */

2025-03-21T15:55:58Z

Microscopic

← Older revision		Revision as of 15:55, 21 March 2025
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	None of the following are present in the cortex:		None of the following are present in the cortex:
	High nuclear grade, high mitotic rate (mitotic activity 1/50 HPF,		High nuclear grade, high mitotic rate (mitotic activity >5/50 HPF,
	where 1 HPF~=0.2376 mm*mm), atypical mitoses, sheeting, necrosis,		where 1 HPF~=0.2376 mm*mm), atypical mitoses, sheeting, necrosis,
	sinusoidal invasion, venous invasion, capsular invasion.		sinusoidal invasion, venous invasion, capsular invasion.

Michael at 15:00, 21 March 2025

2025-03-21T15:00:12Z

← Older revision		Revision as of 15:00, 21 March 2025
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	The serology in adenoma has been associated with certain genes:<ref name=pmid30969728>{{cite journal \|authors=Mahmood E, Loughner CL, Anastasopoulou C \|title= \|journal= \|volume= \|issue= \|pages= \|date= \|pmid=30969728 \|doi= \|url=}}</ref>		The serology in adenoma has been associated with certain genes:<ref name=pmid30969728>{{cite journal \|authors=Mahmood E, Loughner CL, Anastasopoulou C \|title= \|journal= \|volume= \|issue= \|pages= \|date= \|pmid=30969728 \|doi= \|url=}}</ref>
	{\| class="wikitable sortable"		{\| class="wikitable sortable"
	~~\|serology~~		!Serology
	~~\|gene~~(s)		!Gene(s)
	\|-		\|-
	\|non-secreting adenoma		\|non-secreting adenoma

Michael at 14:59, 21 March 2025

2025-03-21T14:59:40Z

← Older revision		Revision as of 14:59, 21 March 2025
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	\| IHC = [[calretinin]], inhibin		\| IHC = [[calretinin]], inhibin
	\| EM =		\| EM =
	\| Molecular = cortisol-producing (PRKACA, GNAS1, MENIN, ARMC5, APC, FH, PRKAR1A, PDE11A, PDE8B), aldosterone-producing		\| Molecular = cortisol-producing (PRKACA, GNAS1, MENIN, ARMC5, APC, FH, PRKAR1A, PDE11A, PDE8B), aldosterone-producing (KCNJ5, ATP1A1, ATP2B3, CACNA1D, CTNNB1), non-secreting (CTNNB1)
	(KCNJ5, ATP1A1, ATP2B3, CACNA1D, CTNNB1), non-secreting (CTNNB1)
	\| IF =		\| IF =
	\| Gross =		\| Gross =

Michael at 14:59, 21 March 2025

2025-03-21T14:59:14Z

← Older revision		Revision as of 14:59, 21 March 2025
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	\| Micro =		\| Micro =
	\| Subtypes =		\| Subtypes =
	\| LMDDx = adrenal cortical nodule, [[adrenal cortical hyperplasia]], [[adrenal cortical carcinoma]]		\| LMDDx = adrenal cortical nodule, adrenal cortical hyperplasia, [[adrenal cortical carcinoma]]
	\| Stains =		\| Stains =
	\| IHC = [[calretinin]], inhibin		\| IHC = [[calretinin]], inhibin
	\| EM =		\| EM =
	\| Molecular =		\| Molecular = cortisol-producing (PRKACA, GNAS1, MENIN, ARMC5, APC, FH, PRKAR1A, PDE11A, PDE8B), aldosterone-producing
			(KCNJ5, ATP1A1, ATP2B3, CACNA1D, CTNNB1), non-secreting (CTNNB1)
	\| IF =		\| IF =
	\| Gross =		\| Gross =
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	\| Clinicalhx =		\| Clinicalhx =
	\| Signs =		\| Signs =
	\| Symptoms =		\| Symptoms =
	\| Prevalence = relatively common		\| Prevalence = relatively common
	\| Bloodwork =		\| Bloodwork = +/-cortisol elevation, +/-aldosterone elevation
	\| Rads = adrenal mass, HU<10		\| Rads = adrenal mass, HU<10
	\| Endoscopy =		\| Endoscopy =

Michael at 14:56, 21 March 2025

2025-03-21T14:56:29Z

← Older revision		Revision as of 14:56, 21 March 2025
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	Note:		Note:
	*Androgen producing adenomas are rare; androgen production more common in [[adrenal cortical carcinoma]].<ref name=pmid30969728>		*Androgen producing adenomas are rare; androgen production more common in [[adrenal cortical carcinoma]].<ref name=pmid30969728/>

	==Microscopic==		==Microscopic==

Michael at 14:56, 21 March 2025

2025-03-21T14:56:09Z

← Older revision		Revision as of 14:56, 21 March 2025
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	*[[Cushing disease]] is due to the ACTH over-production by the [[pituitary]].		*[[Cushing disease]] is due to the ACTH over-production by the [[pituitary]].
	*In cortisol producing tumours (''Cushing syndrome''): atrophy of the non-hyperplastic cortex (due to feedback inhibition from the [[pituitary gland]]).		*In cortisol producing tumours (''Cushing syndrome''): atrophy of the non-hyperplastic cortex (due to feedback inhibition from the [[pituitary gland]]).

			===Serology and genes===
			The serology in adenoma has been associated with certain genes:<ref name=pmid30969728>{{cite journal \|authors=Mahmood E, Loughner CL, Anastasopoulou C \|title= \|journal= \|volume= \|issue= \|pages= \|date= \|pmid=30969728 \|doi= \|url=}}</ref>
			{\| class="wikitable sortable"
			\|serology
			\|gene(s)
			\|-
			\|non-secreting adenoma
			\|CTNNB1
			\|-
			\|cortisol-producing
			\|PRKACA, GNAS1, MENIN, ARMC5, APC, FH, PRKAR1A, PDE11A, PDE8B
			\|-
			\|aldosterone-producing
			\|KCNJ5, ATP1A1, ATP2B3, CACNA1D, CTNNB1
			\|}

			Note:
			*Androgen producing adenomas are rare; androgen production more common in [[adrenal cortical carcinoma]].<ref name=pmid30969728>

	==Microscopic==		==Microscopic==

Michael: fix sp wikify

2020-06-01T14:38:12Z

fix sp wikify

← Older revision		Revision as of 14:38, 1 June 2020
Line 9:		Line 9:
	\| LMDDx = adrenal cortical nodule, [[adrenal cortical hyperplasia]], [[adrenal cortical carcinoma]]		\| LMDDx = adrenal cortical nodule, [[adrenal cortical hyperplasia]], [[adrenal cortical carcinoma]]
	\| Stains =		\| Stains =
	\| IHC = ~~calretin~~, inhibin		\| IHC = [[calretinin]], inhibin
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =
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	==IHC==		==IHC==
	Features:<ref name=pmid11893039>{{cite journal \|authors=Jorda M, De MB, Nadji M \|title=Calretinin and inhibin are useful in separating adrenocortical neoplasms from pheochromocytomas \|journal=Appl. Immunohistochem. Mol. Morphol. \|volume=10 \|issue=1 \|pages=67–70 \|date=March 2002 \|pmid=11893039 \|doi=10.1097/00129039-200203000-00012 \|url=}}</ref>		Features:<ref name=pmid11893039>{{cite journal \|authors=Jorda M, De MB, Nadji M \|title=Calretinin and inhibin are useful in separating adrenocortical neoplasms from pheochromocytomas \|journal=Appl. Immunohistochem. Mol. Morphol. \|volume=10 \|issue=1 \|pages=67–70 \|date=March 2002 \|pmid=11893039 \|doi=10.1097/00129039-200203000-00012 \|url=}}</ref>
	*Calretinin +ve.		*[[Calretinin]] +ve.
	*Inhibin +ve.		*Inhibin +ve.

Michael: +ihc

2020-06-01T14:37:00Z

+ihc

← Older revision		Revision as of 14:37, 1 June 2020
Line 9:		Line 9:
	\| LMDDx = adrenal cortical nodule, [[adrenal cortical hyperplasia]], [[adrenal cortical carcinoma]]		\| LMDDx = adrenal cortical nodule, [[adrenal cortical hyperplasia]], [[adrenal cortical carcinoma]]
	\| Stains =		\| Stains =
	\| IHC =		\| IHC = calretin, inhibin
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =
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	Image: Adrenal LipoAdenoma MP PA.JPG\|Adrenal cortical adenoma with fat - "lipoadenoma" (SKB)		Image: Adrenal LipoAdenoma MP PA.JPG\|Adrenal cortical adenoma with fat - "lipoadenoma" (SKB)
	</gallery>		</gallery>

			==IHC==
			Features:<ref name=pmid11893039>{{cite journal \|authors=Jorda M, De MB, Nadji M \|title=Calretinin and inhibin are useful in separating adrenocortical neoplasms from pheochromocytomas \|journal=Appl. Immunohistochem. Mol. Morphol. \|volume=10 \|issue=1 \|pages=67–70 \|date=March 2002 \|pmid=11893039 \|doi=10.1097/00129039-200203000-00012 \|url=}}</ref>
			*Calretinin +ve.
			*Inhibin +ve.

			Note:
			*Calretinin and inhibin in combination are useful for adrenal versus [[pheochromocytoma]].<ref name=pmid11893039/>

	==Sign out==		==Sign out==

Michael: /* Weiss criteria */ correction - thanks to Jonathan!

2019-05-29T14:04:16Z

Weiss criteria: correction - thanks to Jonathan!

← Older revision		Revision as of 14:04, 29 May 2019
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	#High mitotic rate; >5/50 HPF (@ 40X obj.) - definition suffers from [[HPFitis]].		#High mitotic rate; >5/50 HPF (@ 40X obj.) - definition suffers from [[HPFitis]].
	#Atypical mitoses.		#Atypical mitoses.
	#Cleared cytoplasm in >= 25% of tumour cells.		#Cleared cytoplasm in <= 25% of tumour cells.
	#Sheeting (diffuse architecture) in >= 1/3 of tumour cells.		#Sheeting (diffuse architecture) in >= 1/3 of tumour cells.
	#Necrosis in nests.		#Necrosis in nests.

Michael: /* Microscopic */ fix typo

2018-10-04T18:59:07Z

Microscopic: fix typo

← Older revision		Revision as of 18:59, 4 October 2018
Line 110:		Line 110:

	None of the following are present in the cortex:		None of the following are present in the cortex:
	High nuclear grade, high mitotic ~~rare~~ (mitotic activity 1/50 HPF,		High nuclear grade, high mitotic rate (mitotic activity 1/50 HPF,
	where 1 HPF~=0.2376 mm*mm), atypical mitoses, sheeting, necrosis,		where 1 HPF~=0.2376 mm*mm), atypical mitoses, sheeting, necrosis,
	sinusoidal invasion, venous invasion, capsular invasion.		sinusoidal invasion, venous invasion, capsular invasion.