Adenocarcinoma of the urinary bladder - Revision history

Michael at 18:14, 2 November 2016

2016-11-02T18:14:27Z

← Older revision		Revision as of 18:14, 2 November 2016
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	\| LMDDx = [[urachal carcinoma]], invasive [[urothelial carcinoma]] with glandular differentiation, [[metastatic]] adenocarcinoma, direct extension of [[adenocarcinoma]] from an adjacent structure (esp. [[colorectal adenocarcinoma]])		\| LMDDx = [[urachal carcinoma]], invasive [[urothelial carcinoma]] with glandular differentiation, [[metastatic]] adenocarcinoma, direct extension of [[adenocarcinoma]] from an adjacent structure (esp. [[colorectal adenocarcinoma]])
	\| Stains =		\| Stains =
	\| IHC = CK7 +ve, CK20 +ve, CDX2 +ve (strong, diffuse), beta-catenin +ve (~~membranous~~, ~~not nuclear~~)		\| IHC = CK7 +ve, CK20 +ve, CDX2 +ve (strong, diffuse), beta-catenin -ve (nuclei -ve, membranes +ve)
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =

Michael: /* IHC */

2016-11-02T18:13:47Z

IHC

← Older revision		Revision as of 18:13, 2 November 2016
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	*CK20 +ve.		*CK20 +ve.
	*CDX2 +ve (strong, diffuse).		*CDX2 +ve (strong, diffuse).
	*Beta-catenin +ve (membranous~~, not nuclear~~).		*Beta-catenin -ve (negative nuclear staining, positive membranous staining).
	**[[Colorectal adenocarcinoma]] typically has nuclear staining ''and'' membranous staining.		**[[Colorectal adenocarcinoma]] typically has nuclear staining ''and'' membranous staining.
	*Thrombomodulin +ve/-ve (~60% of cases).		*Thrombomodulin +ve/-ve (~60% of cases).

Michael at 20:10, 14 October 2015

2015-10-14T20:10:03Z

← Older revision		Revision as of 20:10, 14 October 2015
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	**[[Prostatic adenocarcinoma]] - esp. [[ductal adenocarcinoma of the prostate]].		**[[Prostatic adenocarcinoma]] - esp. [[ductal adenocarcinoma of the prostate]].
	**[[Endometrioid endometrial adenocarcinoma]].		**[[Endometrioid endometrial adenocarcinoma]].
	*Tubular adenoma of the urinary tract.<ref name=pmid23664485>{{Cite journal \| last1 = Kao \| first1 = CS. \| last2 = Epstein \| first2 = JI. \| title = Tubular adenoma of the urinary tract: a newly described entity. \| journal = Hum Pathol \| volume = 44 \| issue = 9 \| pages = 1890-4 \| month = Sep \| year = 2013 \| doi = 10.1016/j.humpath.2013.02.017 \| PMID = 23664485 }}</ref>		*[[Tubular adenoma of the urinary tract]].<ref name=pmid23664485>{{Cite journal \| last1 = Kao \| first1 = CS. \| last2 = Epstein \| first2 = JI. \| title = Tubular adenoma of the urinary tract: a newly described entity. \| journal = Hum Pathol \| volume = 44 \| issue = 9 \| pages = 1890-4 \| month = Sep \| year = 2013 \| doi = 10.1016/j.humpath.2013.02.017 \| PMID = 23664485 }}</ref>

	===Images===		===Images===

Michael at 20:09, 14 October 2015

2015-10-14T20:09:36Z

← Older revision		Revision as of 20:09, 14 October 2015
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	**[[Prostatic adenocarcinoma]] - esp. [[ductal adenocarcinoma of the prostate]].		**[[Prostatic adenocarcinoma]] - esp. [[ductal adenocarcinoma of the prostate]].
	**[[Endometrioid endometrial adenocarcinoma]].		**[[Endometrioid endometrial adenocarcinoma]].
			*Tubular adenoma of the urinary tract.<ref name=pmid23664485>{{Cite journal \| last1 = Kao \| first1 = CS. \| last2 = Epstein \| first2 = JI. \| title = Tubular adenoma of the urinary tract: a newly described entity. \| journal = Hum Pathol \| volume = 44 \| issue = 9 \| pages = 1890-4 \| month = Sep \| year = 2013 \| doi = 10.1016/j.humpath.2013.02.017 \| PMID = 23664485 }}</ref>

	===Images===		===Images===

Michael: /* Case 1 */

2015-07-17T01:34:25Z

Case 1

← Older revision		Revision as of 01:34, 17 July 2015
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	====Case 1====		====Case 1====
	<gallery>		<gallery>
	Image: Adenocarcinoma of the urinary bladder -- low mag.jpg \| AUB ~~(invasive)~~ - low mag. (WC)		Image: Adenocarcinoma of the urinary bladder -- low mag.jpg \| Invasive AUB - low mag. (WC)
	Image: Adenocarcinoma of the urinary bladder -- intermed mag.jpg \| AUB - intermed. mag. (WC)		Image: Adenocarcinoma of the urinary bladder -- intermed mag.jpg \| Invasive AUB - intermed. mag. (WC)
	Image: Adenocarcinoma of the urinary bladder -- high mag.jpg \| AUB - high mag. (WC)		Image: Adenocarcinoma of the urinary bladder -- high mag.jpg \| Invasive AUB - high mag. (WC)
	</gallery>		</gallery>

Michael: /* Case 1 - invasive */

2015-07-17T01:33:54Z

Case 1 - invasive

← Older revision		Revision as of 01:33, 17 July 2015
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	===Images===		===Images===
	====Case 1 ~~- invasive~~====		====Case 1====
	<gallery>		<gallery>
	Image: Adenocarcinoma of the urinary bladder -- low mag.jpg \| AUB - low mag. (WC)		Image: Adenocarcinoma of the urinary bladder -- low mag.jpg \| AUB (invasive) - low mag. (WC)
	Image: Adenocarcinoma of the urinary bladder -- intermed mag.jpg \| AUB - intermed. mag. (WC)		Image: Adenocarcinoma of the urinary bladder -- intermed mag.jpg \| AUB - intermed. mag. (WC)
	Image: Adenocarcinoma of the urinary bladder -- high mag.jpg \| AUB - high mag. (WC)		Image: Adenocarcinoma of the urinary bladder -- high mag.jpg \| AUB - high mag. (WC)
	</gallery>		</gallery>

	====Case 2 - AIS====		====Case 2 - AIS====
	<gallery>		<gallery>

Michael: /* Case 1 */

2015-07-17T01:33:20Z

Case 1

← Older revision		Revision as of 01:33, 17 July 2015
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	===Images===		===Images===
	====Case 1====		====Case 1 - invasive====
	<gallery>		<gallery>
	Image: Adenocarcinoma of the urinary bladder -- low mag.jpg \| AUB - low mag. (WC)		Image: Adenocarcinoma of the urinary bladder -- low mag.jpg \| AUB - low mag. (WC)
	Image: Adenocarcinoma of the urinary bladder -- intermed mag.jpg \| AUB - intermed. mag. (WC)		Image: Adenocarcinoma of the urinary bladder -- intermed mag.jpg \| AUB - intermed. mag. (WC)
	Image: Adenocarcinoma of the urinary bladder -- high mag.jpg \| AUB - high mag. (WC)		Image: Adenocarcinoma of the urinary bladder -- high mag.jpg \| AUB - high mag. (WC)
			</gallery>
			====Case 2 - AIS====
			<gallery>
			Image: Adenocarcinoma in situ of bladder -- very low mag.jpg \| Adenocarcinoma in situ (AIS) - very low mag.
			Image: Adenocarcinoma in situ of bladder -- low mag.jpg \| AIS - low mag.
			Image: Adenocarcinoma in situ of bladder -- intermed mag.jpg \| AIS - intermed. mag.
			Image: Adenocarcinoma in situ of bladder -- high mag.jpg \| AIS - high mag.
	</gallery>		</gallery>

Michael: tweak

2015-04-30T21:41:57Z

tweak

← Older revision		Revision as of 21:41, 30 April 2015
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	\| Micro = nuclear pleomorphism (may be mild), usually glandular differentiation (most common), no urothelial differentiation - '''essential'''		\| Micro = nuclear pleomorphism (may be mild), usually glandular differentiation (most common), no urothelial differentiation - '''essential'''
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[urachal carcinoma]], invasive [[urothelial carcinoma]] with glandular differentiation, [[metastatic]] adenocarcinoma (esp. [[colorectal adenocarcinoma]])		\| LMDDx = [[urachal carcinoma]], invasive [[urothelial carcinoma]] with glandular differentiation, [[metastatic]] adenocarcinoma, direct extension of [[adenocarcinoma]] from an adjacent structure (esp. [[colorectal adenocarcinoma]])
	\| Stains =		\| Stains =
	\| IHC = CK7 +ve, CK20 +ve, CDX2 +ve (strong, diffuse), beta-catenin +ve (membranous, not nuclear)		\| IHC = CK7 +ve, CK20 +ve, CDX2 +ve (strong, diffuse), beta-catenin +ve (membranous, not nuclear)

Michael at 21:39, 30 April 2015

2015-04-30T21:39:40Z

← Older revision		Revision as of 21:39, 30 April 2015
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	\| Syndromes =		\| Syndromes =
	\| Clinicalhx =		\| Clinicalhx =
	\| Signs =		\| Signs = +/-hematuria
	\| Symptoms =		\| Symptoms =
	\| Prevalence = rare		\| Prevalence = rare

Michael: /* Microscopic */

2015-04-30T21:38:32Z

Microscopic

← Older revision		Revision as of 21:38, 30 April 2015
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	**Frequently looks just like [[colorectal adenocarcinoma]].		**Frequently looks just like [[colorectal adenocarcinoma]].
	*Without urothelial differentiation - '''essential'''.<ref name=pmid23451748>{{Cite journal \| last1 = Zhong \| first1 = M. \| last2 = Gersbach \| first2 = E. \| last3 = Rohan \| first3 = SM. \| last4 = Yang \| first4 = XJ. \| title = Primary adenocarcinoma of the urinary bladder: differential diagnosis and clinical relevance. \| journal = Arch Pathol Lab Med \| volume = 137 \| issue = 3 \| pages = 371-81 \| month = Mar \| year = 2013 \| doi = 10.5858/arpa.2012-0076-RA \| PMID = 23451748 }}</ref>		*Without urothelial differentiation - '''essential'''.<ref name=pmid23451748>{{Cite journal \| last1 = Zhong \| first1 = M. \| last2 = Gersbach \| first2 = E. \| last3 = Rohan \| first3 = SM. \| last4 = Yang \| first4 = XJ. \| title = Primary adenocarcinoma of the urinary bladder: differential diagnosis and clinical relevance. \| journal = Arch Pathol Lab Med \| volume = 137 \| issue = 3 \| pages = 371-81 \| month = Mar \| year = 2013 \| doi = 10.5858/arpa.2012-0076-RA \| PMID = 23451748 }}</ref>
			*+/-Evidence of invasion such as:
			**[[Desmoplastic stroma]].
			**Extensive disordered or cribriform growth.

	Subtypes:<ref name=pmid23772302>{{Cite journal \| last1 = Abbas \| first1 = M. \| last2 = Kramer \| first2 = MW. \| last3 = Wolters \| first3 = M. \| last4 = Herrman \| first4 = TR. \| last5 = Becker \| first5 = JU. \| last6 = Kreipe \| first6 = HH. \| title = Adenocarcinoma of the urinary bladder, mesonephroid type: a rare case. \| journal = Rare Tumors \| volume = 5 \| issue = 1 \| pages = e3 \| month = Feb \| year = 2013 \| doi = 10.4081/rt.2013.e3 \| PMID = 23772302 }}</ref>		Subtypes:<ref name=pmid23772302>{{Cite journal \| last1 = Abbas \| first1 = M. \| last2 = Kramer \| first2 = MW. \| last3 = Wolters \| first3 = M. \| last4 = Herrman \| first4 = TR. \| last5 = Becker \| first5 = JU. \| last6 = Kreipe \| first6 = HH. \| title = Adenocarcinoma of the urinary bladder, mesonephroid type: a rare case. \| journal = Rare Tumors \| volume = 5 \| issue = 1 \| pages = e3 \| month = Feb \| year = 2013 \| doi = 10.4081/rt.2013.e3 \| PMID = 23772302 }}</ref>
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	*Signet ring cell carcinoma.		*Signet ring cell carcinoma.
	*Clear cell carcinoma (also ''[[mesonephroid carcinoma]]'').		*Clear cell carcinoma (also ''[[mesonephroid carcinoma]]'').

			Note:
			*The presence of [[adenocarcinoma in situ]] suggests the lesion arose in the bladder.{{fact}}

	DDx:		DDx:
	*[[Urachal ~~carcinoma~~]] - dome of bladder.		*[[Urachal adenocarcinoma]] - dome of bladder.
	*Invasive [[urothelial carcinoma]] with glandular differentiation - has urothelial differentiation.		*Invasive [[urothelial carcinoma]] with glandular differentiation - has urothelial differentiation.
	*[[Metastatic]] adenocarcinoma ''or'' extension of [[adenocarcinoma]] from a nearby structure		*[[Metastatic]] adenocarcinoma ''or'' extension of [[adenocarcinoma]] from a nearby structure