Michael: /* Microscopic */

2014-04-23T00:18:20Z

Microscopic

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	DDx:		DDx:
	*[[Ampullary carcinoma]].		*[[Ampullary carcinoma]].
			*[[Duodenal neuroendocrine tumour]].

	==IHC==		==IHC==

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2014-04-23T00:15:42Z

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	~~#redirect~~ [[Duodenum~~#Adenocarcinoma_of_the_duodenum~~]]		'''Adenocarcinoma of the duodenum''' is an uncommon epithelial derived malignancy of the [[duodenum]]. It is frequently associated with [[familial adenomatous polyposis]].

			It is also known as '''duodenal adenocarcinoma''', '''duodenal carcinoma''' and '''carcinoma of the duodenum'''.

			==General==
			*Duodenum - most common site in [[small bowel]].
			**[[Ampulla of Vater]] most common site in the duodenum - see ''[[ampullary carcinoma]]''.

			Risk factors:
			*[[Crohn's disease]].
			*[[Celiac sprue]].
			*[[Familial adenomatous polyposis]] (FAP).
			*[[HNPCC]].
			*[[Peutz-Jeghers syndrome]].

			==Gross==
			*Mass ulcerating or exophytic.

			Image:
			<gallery>
			Image:Duodenal adenocarcinoma.png \| Duodenal adenocarcinoma - endoscopy. (WC/Samir)
			</gallery>

			==Microscopic==
			Features:
			*Similar to large bowel adenocarcinomas - see ''[[colorectal tumours]]'' article.
			**May be similar to gastric adenocarcinomas (gastric-type adenocarcinoma).<ref>{{Cite journal \| last1 = Kushima \| first1 = R. \| last2 = Stolte \| first2 = M. \| last3 = Dirks \| first3 = K. \| last4 = Vieth \| first4 = M. \| last5 = Okabe \| first5 = H. \| last6 = Borchard \| first6 = F. \| last7 = Hattori \| first7 = T. \| title = Gastric-type adenocarcinoma of the duodenal second portion histogenetically associated with hyperplasia and gastric-foveolar metaplasia of Brunner's glands. \| journal = Virchows Arch \| volume = 440 \| issue = 6 \| pages = 655-9 \| month = Jun \| year = 2002 \| doi = 10.1007/s00428-002-0615-z \| PMID = 12070607 }}
			</ref>

			DDx:
			*[[Ampullary carcinoma]].

			==IHC==
			*SMAD4 -ve/+ve.<ref name=pmid15157044>{{Cite journal \| last1 = Bläker \| first1 = H. \| last2 = Aulmann \| first2 = S. \| last3 = Helmchen \| first3 = B. \| last4 = Otto \| first4 = HF. \| last5 = Rieker \| first5 = RJ. \| last6 = Penzel \| first6 = R. \| title = Loss of SMAD4 function in small intestinal adenocarcinomas: comparison of genetic and immunohistochemical findings. \| journal = Pathol Res Pract \| volume = 200 \| issue = 1 \| pages = 1-7 \| month = \| year = 2004 \| doi = \| PMID = 15157044 }}</ref>

			==See also==
			*[[Duodenum]].
			*[[Adenocarcinoma]].

			==References==
			{{Reflist\|2}}

			[[Category:Duodenum]]
			[[Category:Diagnosis]]

Michael: redirect

2012-03-29T19:48:32Z

redirect

New page

#redirect [[Duodenum#Adenocarcinoma_of_the_duodenum]]

Adenocarcinoma of the duodenum - Revision history

Michael: /* Microscopic */

Michael: split out

Michael: redirect