Acinar cell carcinoma of the pancreas - Revision history

Michael at 05:15, 21 October 2014

2014-10-21T05:15:11Z

← Older revision		Revision as of 05:15, 21 October 2014
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	\| Clinicalhx =		\| Clinicalhx =
	\| Signs =		\| Signs =
	\| Symptoms = joint pain		\| Symptoms = +/-joint pain
	\| Prevalence = very rare		\| Prevalence = very rare
	\| Bloodwork = eosinophilia		\| Bloodwork = +/-eosinophilia
	\| Rads = mass lesion - typically head of pancreas		\| Rads = mass lesion - typically head of pancreas
	\| Endoscopy =		\| Endoscopy =

Michael at 05:14, 21 October 2014

2014-10-21T05:14:43Z

← Older revision		Revision as of 05:14, 21 October 2014
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	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[pancreatic neuroendocrine tumour]], [[invasive ductal carcinoma of the pancreas]]		\| LMDDx = [[pancreatic neuroendocrine tumour]], [[invasive ductal carcinoma of the pancreas]]
	\| Stains =		\| Stains = PAS +ve, PASD +ve
	\| IHC = trypsin +ve (key stain), lipase +ve, chromogranin +ve (scattered, focal)		\| IHC = trypsin +ve (key stain), lipase +ve, chromogranin +ve (scattered, focal)
	\| EM =		\| EM =

Michael at 05:14, 21 October 2014

2014-10-21T05:14:15Z

← Older revision		Revision as of 05:14, 21 October 2014
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Acinar_cell_carcinoma_of_the_pancreas_-_very_high_mag.jpg
			\| Width =
			\| Caption = Acinar cell carcinoma. [[H&E stain]].
			\| Synonyms =
			\| Micro = cells reminiscent of pancreatic acinus cells (granular, basophilic cytoplasm - usu. abundant; round/oval nucleus with prominent nucleolus); variable architecture (nests, sheets, trabecular, glandular)
			\| Subtypes =
			\| LMDDx = [[pancreatic neuroendocrine tumour]], [[invasive ductal carcinoma of the pancreas]]
			\| Stains =
			\| IHC = trypsin +ve (key stain), lipase +ve, chromogranin +ve (scattered, focal)
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[pancreas]]
			\| Assdx = subcutaneous [[fat necrosis]], poly[[arthritis]]
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms = joint pain
			\| Prevalence = very rare
			\| Bloodwork = eosinophilia
			\| Rads = mass lesion - typically head of pancreas
			\| Endoscopy =
			\| Prognosis = poor - median survival ~18 mo.
			\| Other =
			\| ClinDDx = other pancreatic tumours
			\| Tx =
			}}
	'''Acinar cell carcinoma of the pancreas''' is a rare malignant epithelial tumour of the [[pancreas]].		'''Acinar cell carcinoma of the pancreas''' is a rare malignant epithelial tumour of the [[pancreas]].

Michael: split out

2014-10-21T05:01:43Z

split out

← Older revision		Revision as of 05:01, 21 October 2014
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	#~~redirect~~ [[Pancreas~~#Acinar_cell_carcinoma_of_the_pancreas~~]]		'''Acinar cell carcinoma of the pancreas''' is a rare malignant epithelial tumour of the [[pancreas]].

			It is also known as '''pancreatic acinar cell carcinoma'''<ref name=pmid>{{Cite journal \| last1 = Thomas \| first1 = PC. \| last2 = Nash \| first2 = GF. \| last3 = Aldridge \| first3 = MC. \| title = Pancreatic acinar cell carcinoma presenting as acute pancreatitis. \| journal = HPB (Oxford) \| volume = 5 \| issue = 2 \| pages = 111-3 \| month = \| year = 2003 \| doi = 10.1080/13651820310001153 \| PMID = 18332967 }}</ref> and '''acinar cell carcinoma'''.

			It should '''not''' to be confused with ''[[acinic cell carcinoma]]'', a tumour of the [[salivary gland]].

			==General==
			*Rare.
			*Solid epithelial exocrine tumour.<ref>URL: [http://brighamrad.harvard.edu/Cases/bwh/hcache/380/full.html http://brighamrad.harvard.edu/Cases/bwh/hcache/380/full.html]. Accessed on: 15 January 2012.</ref>
			*Poor prognosis; mean survival of 18 months in one series.<ref name=pmid1384374/>

			Clinical:<ref name=pmid1384374>{{Cite journal \| last1 = Klimstra \| first1 = DS. \| last2 = Heffess \| first2 = CS. \| last3 = Oertel \| first3 = JE. \| last4 = Rosai \| first4 = J. \| title = Acinar cell carcinoma of the pancreas. A clinicopathologic study of 28 cases. \| journal = Am J Surg Pathol \| volume = 16 \| issue = 9 \| pages = 815-37 \| month = Sep \| year = 1992 \| doi = \| PMID = 1384374 }}</ref>
			*Increased serum lipase.
			**Associated with arthralgias (joint pain).
			*Classic presentation - Schmid triad:<ref name=pmid20168061>{{Cite journal \| last1 = Jang \| first1 = SH. \| last2 = Choi \| first2 = SY. \| last3 = Min \| first3 = JH. \| last4 = Kim \| first4 = TW. \| last5 = Lee \| first5 = JA. \| last6 = Byun \| first6 = SJ. \| last7 = Lee \| first7 = JW. \| title = [A case of acinar cell carcinoma of pancreas, manifested by subcutaneous nodule as initial clinical symptom]. \| journal = Korean J Gastroenterol \| volume = 55 \| issue = 2 \| pages = 139-43 \| month = Feb \| year = 2010 \| doi = \| PMID = 20168061 }}</ref>
			*#Subcutaneous [[fat necrosis]].
			*#Polyarthritis.
			*#Eosinophilia.

			==Gross==
			*Usually head of pancreas.

			==Microscopic==
			Features:<ref name=pmid1384374/>
			*Cells reminiscent of pancreatic acinus cells:
			**Granular, basophilic cytoplasm - usu. abundant.
			**Round/oval nucleus.
			***Nucleolus prominent.
			*Architecture:
			**Nests, sheets, trabecular, glandular.

			DDx:
			*[[Pancreatic neuroendocrine tumour]].
			*[[Invasive ductal carcinoma of the pancreas]].

			===Images===
			<gallery>
			Image:Acinar_cell_carcinoma_of_the_pancreas_-_high_mag.jpg \| Pancreatic acinar cell carcinoma - high mag. (WC/Nephron)
			Image:Acinar_cell_carcinoma_of_the_pancreas_-_very_high_mag.jpg \| Pancreatic acinar cell carcinoma - very high mag. (WC/Nephron)
			</gallery>
			www:
			*[http://path.upmc.edu/cases/case377.html Acinar cell carcinoma - several images (upmc.edu)].
			*[http://brighamrad.harvard.edu/Cases/bwh/hcache/380/full.html Acinar cell carcinoma - several images (harvard.edu)].
			*[http://www.nature.com/modpathol/journal/v20/n1s/fig_tab/3800686f12.html#figure-title Acinar cell carcinoma - 1 (nature.com)].
			*[http://www.nature.com/modpathol/journal/v20/n1s/fig_tab/3800686f13.html#figure-title Acinar cell carcinoma - 2 (nature.com)].<ref name=pmid17486055>{{Cite journal \| last1 = Klimstra \| first1 = DS. \| title = Nonductal neoplasms of the pancreas. \| journal = Mod Pathol \| volume = 20 Suppl 1 \| issue = \| pages = S94-112 \| month = Feb \| year = 2007 \| doi = 10.1038/modpathol.3800686 \| PMID = 17486055 }}</ref>
			==Stains==
			Features:<ref name=pmid1384374/>
			*PAS +ve (granular).
			*PASD +ve.

			==IHC==
			*Trypsin +ve -- '''key stain'''.
			*Lipase +ve.
			*Chromogranin +ve (scattered, focal).
			*CD56 -ve. (?)

			==See also==
			*[[Pancreas]].

			==References==
			{{Reflist\|2}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Pancreas]]

Michael: redirect

2012-01-15T23:18:28Z

redirect

New page

#redirect [[Pancreas#Acinar_cell_carcinoma_of_the_pancreas]]

[[Category:Diagnosis]]