View source for WT-1

[[File:Wilms_tumor_protein_wt1_immunohistocehmistry_glioblastoma.JPG|thumb|right|250px|WT-1 staining in [[glioblastoma]].]]
'''Wilms Tumor Protein 1''', commonly known by the abbreviation '''WT-1''', is a commonly used [[immunostain]] in [[gynecologic pathology]] and [[neuropathology]].

==Tumours with positive staining==
*[[Astrocytoma]]/[[Glioblastoma]] (cytoplasmic) ~80-90%.<ref name=pmid18466223>{{Cite journal  | last1 = Schittenhelm | first1 = J. | last2 = Beschorner | first2 = R. | last3 = Simon | first3 = P. | last4 = Tabatabai | first4 = G. | last5 = Herrmann | first5 = C. | last6 = Schlaszus | first6 = H. | last7 = Capper | first7 = D. | last8 = Weller | first8 = M. | last9 = Meyermann | first9 = R. | title = Diagnostic value of WT1 in neuroepithelial tumours. | journal = Neuropathol Appl Neurobiol | volume = 35 | issue = 1 | pages = 69-81 | month = Feb | year = 2009 | doi = 10.1111/j.1365-2990.2008.00957.x | PMID = 18466223 }}</ref>
*[[Malignant mesothelioma]].<ref name=pmid16554731>{{Cite journal  | last1 = Yaziji | first1 = H. | last2 = Battifora | first2 = H. | last3 = Barry | first3 = TS. | last4 = Hwang | first4 = HC. | last5 = Bacchi | first5 = CE. | last6 = McIntosh | first6 = MW. | last7 = Kussick | first7 = SJ. | last8 = Gown | first8 = AM. | title = Evaluation of 12 antibodies for distinguishing epithelioid mesothelioma from adenocarcinoma: identification of a three-antibody immunohistochemical panel with maximal sensitivity and specificity. | journal = Mod Pathol | volume = 19 | issue = 4 | pages = 514-23 | month = Apr | year = 2006 | doi = 10.1038/modpathol.3800534 | PMID = 16554731 }}</ref>

===Gynecologic pathology===
*[[Serous ovarian carcinoma]].<ref name=pmid14764054>{{Cite journal  | last1 = Al-Hussaini | first1 = M. | last2 = Stockman | first2 = A. | last3 = Foster | first3 = H. | last4 = McCluggage | first4 = WG. | title = WT-1 assists in distinguishing ovarian from uterine serous carcinoma and in distinguishing between serous and endometrioid ovarian carcinoma. | journal = Histopathology | volume = 44 | issue = 2 | pages = 109-15 | month = Feb | year = 2004 | doi =  | PMID = 14764054 }}</ref>

===Kidney pathology===
*[[Wilms tumour]].
*[[Metanephric adenoma]].<ref name=pmid24083046>{{Cite journal  | last1 = Watanabe | first1 = S. | last2 = Naganuma | first2 = H. | last3 = Shimizu | first3 = M. | last4 = Ota | first4 = S. | last5 = Murata | first5 = S. | last6 = Nihei | first6 = N. | last7 = Matsushima | first7 = J. | last8 = Mikami | first8 = S. | last9 = Kuroda | first9 = N. | title = Adult nephroblastoma with predominant epithelial component: a differential diagnostic candidate of papillary renal cell carcinoma and metanephric adenoma-report of three cases. | journal = Case Rep Pathol | volume = 2013 | issue =  | pages = 675875 | month =  | year = 2013 | doi = 10.1155/2013/675875 | PMID = 24083046 }}</ref>

==Usually negative==
*[[Serous carcinoma of the endometrium]].<ref name=pmid10786803>{{Cite journal  | last1 = Kounelis | first1 = S. | last2 = Kapranos | first2 = N. | last3 = Kouri | first3 = E. | last4 = Coppola | first4 = D. | last5 = Papadaki | first5 = H. | last6 = Jones | first6 = MW. | title = Immunohistochemical profile of endometrial adenocarcinoma: a study of 61 cases and review of the literature. | journal = Mod Pathol | volume = 13 | issue = 4 | pages = 379-88 | month = Apr | year = 2000 | doi = 10.1038/modpathol.3880062 | PMID = 10786803 }}</ref>

==See also==
*[[Immunostains]].

==References==
{{Reflist|1}}

==External links==
*[http://www.nordiqc.org/Epitopes/WT1/WT1.htm WT-1(nordiqc.org)].

[[Category:Immunohistochemistry]]
[[Category:Neuropathology]]