View source for Stratified mucin-producing intraepithelial lesion of the cervix

'''Stratified mucin-producing intraepithelial lesion of the cervix''' is a rare dysplastic lesion of the [[uterine cervix]].  It is considered to be a high-grade lesion with overlapping features of [[endocervical adenocarcinoma in situ]] and [[squamous intraepithelial lesion]].<ref name=pmid25039487/>

It is abbreviated '''SMILE''' ('''S'''tratified '''M'''ucin-producing '''I'''ntraepithelial '''LE'''sion).

==General==
*Rare ~0.6% of cervix lesions in one series.<ref name=pmid25039487>{{Cite journal  | last1 = Boyle | first1 = DP. | last2 = McCluggage | first2 = WG. | title = Stratified mucin-producing intraepithelial lesion (SMILE): report of a case series with associated pathological findings. | journal = Histopathology | volume = 66 | issue = 5 | pages = 658-63 | month = Apr | year = 2015 | doi = 10.1111/his.12498 | PMID = 25039487 }}</ref>
*Often accompanied by [[cervical intraepithelial neoplasia]] and [[adenocarcinoma in situ]].<ref name=pmid11023104/>

Management:
*Like [[endocervical AIS]].<ref name=pmid25039487/>

==Microscopic==
Features:<ref name=pmid11023104>{{Cite journal  | last1 = Park | first1 = JJ. | last2 = Sun | first2 = D. | last3 = Quade | first3 = BJ. | last4 = Flynn | first4 = C. | last5 = Sheets | first5 = EE. | last6 = Yang | first6 = A. | last7 = McKeon | first7 = F. | last8 = Crum | first8 = CP. | title = Stratified mucin-producing intraepithelial lesions of the cervix: adenosquamous or columnar cell neoplasia? | journal = Am J Surg Pathol | volume = 24 | issue = 10 | pages = 1414-9 | month = Oct | year = 2000 | doi =  | PMID = 11023104 }}</ref>
*Stratified epithelium with:
**Nuclear atypia.
**Cytoplasmic clearing or vacuoles in lesions - through-out.

DDx:
*[[HSIL]].
**Mucin may be present superficially.<ref name=pmid11023104/>
*[[Endocervical AIS]].

===Images===
*[http://sunnybrook.ca/uploads/cx_SMILE_S10-1021_vd_1.jpg SMILE (sunnybrook.ca)].<ref>URL: [http://sunnybrook.ca/content/?page=Dept_LabS_APath_GynPath_ImgAt_Cvx_mal_ais_smile http://sunnybrook.ca/content/?page=Dept_LabS_APath_GynPath_ImgAt_Cvx_mal_ais_smile]. Accessed on: 30 March 2012.</ref>
*[http://sunnybrook.ca/uploads/cx_SMILE_S10-1021_vd_2.jpg SMILE (sunnybrook.ca)].

==IHC==
Features:
*Ki-67 high.
*Keratin 14 -ve.
*p63 +ve/-ve -- only basal if positive.

==See also==
*[[Uterine cervix]].

==References==
{{Reflist|1}}

[[Category:Diagnosis]]
[[Category:Uterine cervix]]