View source for Mucinous adenocarcinoma of the prostate

{{ Infobox diagnosis
| Name       = {{PAGENAME}}
| Image      = Mucinous adenocarcinoma of prostate - 2b -- high mag.jpg
| Width      =
| Caption    = Mucinous adenocarcinoma of the prostate (left of image) with acinar adenocarcinoma of the prostate (right of image). [[H&E stain]]. (WC/Nephron)
| Synonyms   =
| Micro      = cytologically malignant (prostatic) cells floating in mucin; >25% of tumour mucinous
| Subtypes   =
| LMDDx      = acinar adenocarcinoma of the prostate with a minor mucinous component (<25%), metastatic [[mucinous carcinoma]], mucinous adenocarcinoma of the prostatic urethra
| Stains     =
| IHC        =
| EM         =
| Molecular  =
| IF         =
| Gross      =
| Grossing   = [[prostatectomy grossing]], [[TURP specimens]]
| Staging    =
| Site       = [[prostate gland]] - see ''[[prostate cancer]]''
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms   =
| Prevalence = rare
| Bloodwork  = PSA elevated
| Rads       =
| Endoscopy  =
| Prognosis  = dependent on grade
| Other      =
| ClinDDx    =
| Tx         = prostatectomy, radiation or observation
}}
'''Mucinous adenocarcinoma of the prostate''' is an uncommon type of [[prostate cancer]].

==General==
*Rare.<ref name=pmid18300802/>
*Most often Gleason 3+4 ~ 80% in one series of 47 cases.<ref name=pmid18300802>{{Cite journal  | last1 = Osunkoya | first1 = AO. | last2 = Nielsen | first2 = ME. | last3 = Epstein | first3 = JI. | title = Prognosis of mucinous adenocarcinoma of the prostate treated by radical prostatectomy: a study of 47 cases. | journal = Am J Surg Pathol | volume = 32 | issue = 3 | pages = 468-72 | month = Mar | year = 2008 | doi = 10.1097/PAS.0b013e3181589f72 | PMID = 18300802 }}</ref>

Gleason pattern:
*In the past, it has been suggested that the mucinous component be assigned ''Gleason pattern 4''.<ref name=pmid14976541>{{cite journal |author=Grignon DJ |title=Unusual subtypes of prostate cancer |journal=Mod. Pathol. |volume=17 |issue=3 |pages=316–27 |year=2004 |month=March |pmid=14976541 |doi=10.1038/modpathol.3800052 |url=}}</ref>
*The prognosis is similar or may be better than the conventional type of prostate cancer in a large series;<ref name=pmid18300802/> thus, it seems reasonable to grade based on the pattern (as advocated by some experts<ref name=pmid18487999>{{Cite journal  | last1 = Osunkoya | first1 = AO. | last2 = Adsay | first2 = NV. | last3 = Cohen | first3 = C. | last4 = Epstein | first4 = JI. | last5 = Smith | first5 = SL. | title = MUC2 expression in primary mucinous and nonmucinous adenocarcinoma of the prostate: an analysis of 50 cases on radical prostatectomy. | journal = Mod Pathol | volume = 21 | issue = 7 | pages = 789-94 | month = Jul | year = 2008 | doi = 10.1038/modpathol.2008.47 | PMID = 18487999 }}</ref>).

==Microscopic==
Features:
*Cytologically malignant cells floating in mucin.
*> 25% of tumour mucinous.<ref name=pmid14976541>{{cite journal |author=Grignon DJ |title=Unusual subtypes of prostate cancer |journal=Mod. Pathol. |volume=17 |issue=3 |pages=316–27 |year=2004 |month=March |pmid=14976541 |doi=10.1038/modpathol.3800052 |url=}}</ref> 
**Two studies suggests '''>=''' 25%.<ref>{{cite journal |author=Osunkoya AO, Nielsen ME, Epstein JI |title=Prognosis of mucinous adenocarcinoma of the prostate treated by radical prostatectomy: a study of 47 cases |journal=Am. J. Surg. Pathol. |volume=32 |issue=3 |pages=468–72 |year=2008 |month=March |pmid=18300802 |doi=10.1097/PAS.0b013e3181589f72 |url=}}</ref><ref name=pmid23060063>{{Cite journal  | last1 = Bohman | first1 = KD. | last2 = Osunkoya | first2 = AO. | title = Mucin-producing tumors and tumor-like lesions involving the prostate: a comprehensive review. | journal = Adv Anat Pathol | volume = 19 | issue = 6 | pages = 374-87 | month = Nov | year = 2012 | doi = 10.1097/PAP.0b013e318271a361 | PMID = 23060063 }}</ref>

Notes:
*[[Mucinous carcinoma]] - percentage required to call varies by site.

DDx:
*Metastatic [[mucinous carcinoma]].
*Mucinous adenocarcinoma of the prostatic urethra - analogous to the mucinous adenocarcinoma of the [[urinary bladder]].<ref name=pmid23060063/>

===Images===
<gallery>
Image: Mucinous adenocarcinoma of prostate -- low mag.jpg | MAP - low mag. (WC/Nephron)
Image: Mucinous adenocarcinoma of prostate -- intermed mag.jpg | MAP - intermed. mag. (WC/Nephron)
Image: Mucinous adenocarcinoma of prostate -- high mag.jpg | MAP - high mag. (WC/Nephron)
Image: Mucinous adenocarcinoma of prostate -- very high mag.jpg | MAP - very high mag. (WC/Nephron)

Image: Mucinous adenocarcinoma of prostate - alt -- low mag.jpg | MAP - low mag. (WC/Nephron)

Image: Mucinous adenocarcinoma of prostate - 2 -- intermed mag.jpg | MAP - intermed. mag. (WC/Nephron)
Image: Mucinous adenocarcinoma of prostate - 2a -- high mag.jpg | MAP - high mag. (WC/Nephron)
Image: Mucinous adenocarcinoma of prostate - 2b -- high mag.jpg | MAP - high mag. (WC/Nephron)
</gallery>

==See also==
*[[Prostate cancer]].
*[[Mucinous adenocarcinoma]].

==References==
{{Reflist|1}}

[[Category:Diagnosis]]
[[Category:Prostate carcinoma]]