View source for Human papillomavirus-related multiphenotypic sinonasal carcinoma

'''Human papillomavirus-related multiphenotypic sinonasal carcinoma''', abbreviated '''HPV-related multiphenotypic sinonasal carcinoma''', is a rare [[cancer|malignant]] tumour of the [[head and neck pathology|head and neck]].<ref>{{Cite journal  | last1 = Bishop | first1 = JA. | last2 = Andreasen | first2 = S. | last3 = Hang | first3 = JF. | last4 = Bullock | first4 = MJ. | last5 = Chen | first5 = TY. | last6 = Franchi | first6 = A. | last7 = Garcia | first7 = JJ. | last8 = Gnepp | first8 = DR. | last9 = Gomez-Fernandez | first9 = CR. | title = HPV-related Multiphenotypic Sinonasal Carcinoma: An Expanded Series of 49 Cases of the Tumor Formerly Known as HPV-related Carcinoma With Adenoid Cystic Carcinoma-like Features. | journal = Am J Surg Pathol | volume = 41 | issue = 12 | pages = 1690-1701 | month = Dec | year = 2017 | doi = 10.1097/PAS.0000000000000944 | PMID = 28877065 }}</ref>

It is also known as '''human papillomavirus-related carcinoma with adenoid cystic-like features''' (abbreviated '''HPV-related carcinoma with AdCC-like features''').<ref name=pmid28035703>{{Cite journal  | last1 = Andreasen | first1 = S. | last2 = Bishop | first2 = JA. | last3 = Hansen | first3 = TV. | last4 = Westra | first4 = WH. | last5 = Bilde | first5 = A. | last6 = von Buchwald | first6 = C. | last7 = Kiss | first7 = K. | title = Human papillomavirus-related carcinoma with adenoid cystic-like features of the sinonasal tract: clinical and morphological characterization of six new cases. | journal = Histopathology | volume = 70 | issue = 6 | pages = 880-888 | month = May | year = 2017 | doi = 10.1111/his.13162 | PMID = 28035703 }}</ref> 
==General==
*Very rare diagnosis - recently described.<ref>{{Cite journal  | last1 = Bishop | first1 = JA. | last2 = Ogawa | first2 = T. | last3 = Stelow | first3 = EB. | last4 = Moskaluk | first4 = CA. | last5 = Koch | first5 = WM. | last6 = Pai | first6 = SI. | last7 = Westra | first7 = WH. | title = Human papillomavirus-related carcinoma with adenoid cystic-like features: a peculiar variant of head and neck cancer restricted to the sinonasal tract. | journal = Am J Surg Pathol | volume = 37 | issue = 6 | pages = 836-44 | month = Jun | year = 2013 | doi = 10.1097/PAS.0b013e31827b1cd6 | PMID = 23598962 }}</ref>
*Associated with [[human papillomavirus]] (HPV).
*An analogous tumour has been described in the [[breast pathology|breast]].<ref name=pmid33218360>{{cite journal |authors=Oramas DM, Bell D, Middleton LP |title=Sinonasal analogue HPV related breast multiphenotypic carcinoma, a report of a case with the first description in the breast |journal=Diagn Pathol |volume=15 |issue=1 |pages=137 |date=November 2020 |pmid=33218360 |pmc=7678216 |doi=10.1186/s13000-020-01050-7 |url=}}</ref>

==Microscopic==
Features:
*Adenoid cystic carcinoma-like morphology with:
**Squamous dysplasia of surface epithelium.
**Squamous differentiation within tumour.

Notes:
*[[Perineural invasion]] rare.
*Bony invasion rare.

DDx:
*[[Adenoid cystic carcinoma]].
*Basaloid [[Squamous cell carcinoma of the head and neck|squamous cell carcinoma]].

==IHC==
*p16 +ve in >= 75% of cells.<ref name=pmid28664668>{{Cite journal  | last1 = Hang | first1 = JF. | last2 = Hsieh | first2 = MS. | last3 = Li | first3 = WY. | last4 = Chen | first4 = JY. | last5 = Lin | first5 = SY. | last6 = Liu | first6 = SH. | last7 = Pan | first7 = CC. | last8 = Kuo | first8 = YJ. | title = Human Papillomavirus-related Carcinoma with Adenoid Cystic-like Features: A Series of 5 Cases Expanding the Pathologic Spectrum. | journal = Histopathology | volume =  | issue =  | pages =  | month = Jun | year = 2017 | doi = 10.1111/his.13301 | PMID = 28664668 }}</ref>
*SOX10 +ve (4 of 4<ref name=pmid31571045>{{cite journal |authors=Rupp NJ, Camenisch U, Seidl K, Rushing EJ, Anderegg N, Broglie MA, Holzmann D, Morand GB |title=HPV-Related Multiphenotypic Sinonasal Carcinoma: Four Cases that Expand the Morpho-Molecular Spectrum and Include Occupational Data |journal=Head Neck Pathol |volume=14 |issue=3 |pages=623–629 |date=September 2020 |pmid=31571045 |pmc=7413931 |doi=10.1007/s12105-019-01079-1 |url=}}</ref>).

==See also==
*[[Salivary gland tumours]].
*[[Biphenotypic sinonasal sarcoma]].

==References==
{{Reflist|1}}

[[Category:Diagnosis]]
[[Category:Head and neck pathology]]