View source for BAP1

'''BAP1''', an abbreviation of '''[[BRCA1]]-Associated Protein 1''', is an [[immunostain]] that is used in the diagnosis of [[malignant mesothelioma]].<ref>{{cite journal |vauthors=Louie BH, Kurzrock R |title=BAP1: Not just a BRCA1-associated protein |journal=Cancer Treat Rev |volume=90 |issue= |pages=102091 |date=November 2020 |pmid=32877777 |pmc=7655689 |doi=10.1016/j.ctrv.2020.102091 |url=}}</ref>

==Loss of staining==
*[[Malignant mesothelioma]] -ve<ref name=pmid29085180>{{cite journal |authors=Pulford E, Huilgol K, Moffat D, Henderson DW, Klebe S |title=Malignant Mesothelioma, BAP1 Immunohistochemistry, and VEGFA: Does BAP1 Have Potential for Early Diagnosis and Assessment of Prognosis? |journal=Dis Markers |volume=2017 |issue= |pages=1310478 |date=2017 |pmid=29085180 |pmc=5612603 |doi=10.1155/2017/1310478 |url=}}</ref> ~57%.<ref name=pmid26226841>{{cite journal |authors=Andrici J, Sheen A, Sioson L, Wardell K, Clarkson A, Watson N, Ahadi MS, Farzin M, Toon CW, Gill AJ |title=Loss of expression of BAP1 is a useful adjunct, which strongly supports the diagnosis of mesothelioma in effusion cytology |journal=Mod Pathol |volume=28 |issue=10 |pages=1360–8 |date=October 2015 |pmid=26226841 |pmc=4761613 |doi=10.1038/modpathol.2015.87 |url=}}</ref>

==Normal staining==
*[[Well-differentiated papillary mesothelial tumour]] - retained (normal) nuclear staining.<ref name=pmid35440764>{{cite journal |authors=Churg A, Galateau-Salle F |title=Well differentiated papillary mesothelial tumor: a new name and new problems |journal=Mod Pathol |volume=35 |issue=10 |pages=1327–1333 |date=October 2022 |pmid=35440764 |doi=10.1038/s41379-022-01082-y |url=}}</ref>

==See also==
*[[Claudin-4]].
*[[HEG1]].

==References==
{{Reflist|2}}

[[Category:Immunohistochemistry]]