View source for DOG1

'''DOG1''' is a common [[immunostain]] classically used to diagnosis [[gastrointestinal stromal tumour]].

==Positive==
*[[Gastrointestinal stromal tumour]] ~ 94% of cases.<ref name=pmid19606013 >{{Cite journal  | last1 = Miettinen | first1 = M. | last2 = Wang | first2 = ZF. | last3 = Lasota | first3 = J. | title = DOG1 antibody in the differential diagnosis of gastrointestinal stromal tumors: a study of 1840 cases. | journal = Am J Surg Pathol | volume = 33 | issue = 9 | pages = 1401-8 | month = Sep | year = 2009 | doi = 10.1097/PAS.0b013e3181a90e1a | PMID = 19606013 }}</ref>
*[[Chromophobe renal cell carcinoma]] - 32 +ve of 37 cases.<ref name=pmid26678977>{{Cite journal  | last1 = Swalchick | first1 = W. | last2 = Shamekh | first2 = R. | last3 = Bui | first3 = MM. | title = Is DOG1 Immunoreactivity Specific to Gastrointestinal Stromal Tumor? | journal = Cancer Control | volume = 22 | issue = 4 | pages = 498-504 | month = Oct | year = 2015 | doi =  | PMID = 26678977 }}</ref>
*[[Renal oncocytoma]].

===Occasional positive===
*Retroperitoneal [[leiomyoma]].<ref name=pmid19606013/>
*Peritoneal leiomyomatosis.<ref name=pmid19606013/>
*[[Synovial sarcoma]].<ref name=pmid19606013/>

Note: 
*There are different clones for DOG1 and the [[sensitivity]] and [[specificity]] are not the same.<ref name=pmid20571340>{{Cite journal  | last1 = Lopes | first1 = LF. | last2 = West | first2 = RB. | last3 = Bacchi | first3 = LM. | last4 = van de Rijn | first4 = M. | last5 = Bacchi | first5 = CE. | title = DOG1 for the diagnosis of gastrointestinal stromal tumor (GIST): Comparison between 2 different antibodies. | journal = Appl Immunohistochem Mol Morphol | volume = 18 | issue = 4 | pages = 333-7 | month = Jul | year = 2010 | doi = 10.1097/PAI.0b013e3181d27ec8 | PMID = 20571340 }}</ref>
==See also==
*[[Immunohistochemistry]].

==References==
{{Reflist|1}}

[[Category:Immunohistochemistry]]