View source for WT-1

[[File:Wilms_tumor_protein_wt1_immunohistocehmistry_glioblastoma.JPG|thumb|right|250px|WT-1 staining in [[glioblastoma]].]]
'''Wilms Tumor Protein 1''', commonly known by the abbreviation '''WT-1''', is a commonly used [[immunostain]] in [[gynecologic pathology]] and [[neuropathology]].

==Tumours with positive staining==
*[[Astrocytoma]]/[[Glioblastoma]] (cytoplasmic) ~80-90% <ref>{{Cite journal  | last1 = Schittenhelm | first1 = J. | last2 = Beschorner | first2 = R. | last3 = Simon | first3 = P. | last4 = Tabatabai | first4 = G. | last5 = Herrmann | first5 = C. | last6 = Schlaszus | first6 = H. | last7 = Capper | first7 = D. | last8 = Weller | first8 = M. | last9 = Meyermann | first9 = R. | title = Diagnostic value of WT1 in neuroepithelial tumours. | journal = Neuropathol Appl Neurobiol | volume = 35 | issue = 1 | pages = 69-81 | month = Feb | year = 2009 | doi = 10.1111/j.1365-2990.2008.00957.x | PMID = 18466223 }}</ref>
*[[Mesothelioma]]<ref>{{Cite journal  | last1 = Yaziji | first1 = H. | last2 = Battifora | first2 = H. | last3 = Barry | first3 = TS. | last4 = Hwang | first4 = HC. | last5 = Bacchi | first5 = CE. | last6 = McIntosh | first6 = MW. | last7 = Kussick | first7 = SJ. | last8 = Gown | first8 = AM. | title = Evaluation of 12 antibodies for distinguishing epithelioid mesothelioma from adenocarcinoma: identification of a three-antibody immunohistochemical panel with maximal sensitivity and specificity. | journal = Mod Pathol | volume = 19 | issue = 4 | pages = 514-23 | month = Apr | year = 2006 | doi = 10.1038/modpathol.3800534 | PMID = 16554731 }}</ref>
*Serous [[ovarian carcinoma]]<ref>{{Cite journal  | last1 = Al-Hussaini | first1 = M. | last2 = Stockman | first2 = A. | last3 = Foster | first3 = H. | last4 = McCluggage | first4 = WG. | title = WT-1 assists in distinguishing ovarian from uterine serous carcinoma and in distinguishing between serous and endometrioid ovarian carcinoma. | journal = Histopathology | volume = 44 | issue = 2 | pages = 109-15 | month = Feb | year = 2004 | doi =  | PMID = 14764054 }}</ref>

==See also==
*[[Immunostains]].

==References==
{{Reflist|1}}

==External links==
*[http://www.nordiqc.org/Epitopes/WT1/WT1.htm WT-1(nordiqc.org)].

[[Category:Immunohistochemistry]]